IL3 Signaling Pathway

Interleukin-3 promotes the proliferation and differentiation of hematopoietic cells through binding to its receptor. The receptor for IL-3 is a heterodimer with a ligand-specific alpha chain (70 kD, CD123) and a common beta chain (shared with IL-5 and GM-CSF). Signaling is believed to be primarily through Stat5 and the MAPK pathways. (NCI Thesaurus/BIOCARTA)

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IL3 Gene

This gene plays a role in hematopoiesis and has neurotrophic activity.

IL2RG wt Allele

Human IL2RG wild-type allele is located in the vicinity of Xq13.1 and is approximately 4 kb in length. This allele, which encodes…

IL2RG Gene

This gene plays a role in immune function and mediates T-cell responses.

IL2RB wt Allele

Human IL2RB wild-type allele is located in the vicinity of 22q13.1 and is approximately 24 kb in length. This allele, which encodes…

IL2RB Pathway

The IL-2 receptor is a key component of immune signaling and is required for the activation, proliferation, and survival of T…

IL2RB Gene

This gene is involved in the regulation of myeloid cell development.