| Health / Medical Topics |
Imetelstat Sodium
The sodium salt of imetelstat, a synthetic lipid-conjugated, 13-mer oligonucleotide N3' P5'-thio-phosphoramidate with potential antineoplastic activity. Complementary to the template region of telomerase RNA (hTR), imetelstat acts as a competitive enzyme inhibitor that binds and blocks the active site of the enzyme (a "telomerase template antagonist"), a mechanism of action which differs from that for the antisense oligonucleotide-mediated inhibition of telomerase activity through telomerase mRNA binding. Inhibition of telomerase activity in tumor cells by imetelstat results in telomere shortening, which leads to cell cycle arrest or apoptosis. (NCI Thesaurus)
YOU MAY ALSO LIKE
A synthetic lipid-conjugated, 13-mer oligonucleotide N3'-P5'-thio-phosphoramidate with potential antineoplastic activity. Complementary to the template region of telomerase (hTR) RNA, imetelstat acts as…
A substance being studied in the treatment of some types of cancer. It is a monoclonal antibody that is made in the…
A substance being studied in the treatment of glioblastoma (a type of brain tumor) that has come back. It binds to receptors…
A monoclonal antibody that selectively binds with KDR and blocks the vascular endothelial growth factor-induced endothelial cell proliferation and prevents angiogenesis. …
A substance being studied in the treatment of breast cancer that has come back. It binds to receptors for a protein called…
A drug used to treat mantle cell lymphoma in patients who have already received other treatment. It is also being studied in…
