| Health / Medical Topics |
In 111 Monoclonal Antibody Anti-TAC
A humanized IgG1 form of the mouse monoclonal antibody (MoAb) anti-Tac with anti-leukemic activity. This MoAb recognizes human IL-2 receptor alpha chain (CD25) and blocks the interaction of IL-2 with IL-2 receptor, and thus prevents activation of T-cells in some leukemia and lymphomas as well as some autoimmune disorders. In addition, this antibody is radiolabeled with gamma emitting radionuclide Indium-111, thereby targeting the Indium radioisotope to the cancer cells which results in non-repairable DNA double-stranded breaks and subsequent cell death. (NCI Thesaurus)
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