Incadronic Acid

A third-generation amino-bisphosphonate with anti-resorptive activity. Although the exact mechanism of action has yet to be fully elucidated, incadronic acid binds to and adsorbs onto hydroxyapatite crystals in the bone matrix, thereby preventing osteoclast resorption. This agent also binds to and inhibits farnesyl pyrophosphate synthase, an enzyme that plays an important role in the mevalonate pathway. This inhibits the formation of isoprenoids that are essential for protein prenylation. This prevents farnesylation and geranylgeranylation of proteins essential for osteoclast function, thereby leading to the induction of apoptosis of osteoclasts. By preventing osteoclast-mediated bone resorption, incadronic acid prevents bone destruction. (NCI Thesaurus)

YOU MAY ALSO LIKE

Inbred Strain

A strain that has been maintained by sibling (sister x brother) matings for 20 or more consecutive generations. (from JAX Strain Information)…

Inbred Mouse Strains

Any strain of mouse that is the product of a mating between close relatives. In biological research, inbreeding allows for the selection…

Inborn Urea Cycle Disorder

A genetic inborn error of metabolism characterized by the deficiency of one of the enzymes necessary for the urea cycle. It results…

Inappropriate Sinus Tachycardia by ECG Finding

An electrocardiographic finding of supraventricular tachycardia involving the sinus node in which a patient has an atypically high heart rate which cannot…

Inappropriate Shock Medical Device Problem

Issue associated with the inappropriate delivery of an electrical energy.

Inappropriate or Insufficient Device Sterilization Evaluation Result

Inadequate sterilization of a device possibly resulting in the presence of microorganisms or other contaminants on the device.