Ingenol Mebutate

A selective small-molecule activator of protein kinase C (PKC) isolated from the plant Euphorbia peplus with potential antineoplastic activity. Ingenol mebutate activates various protein kinase C (PKC) isoforms, thereby inducing apoptosis in some tumor cells, including myeloid leukemia cells, melanoma cells, and basal cell carcinoma cells. The PKC family consists of signaling isoenzymes that regulate many cell processes including proliferation, differentiation, and apoptosis. (NCI Thesaurus)

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ING2 wt Allele

Human ING2 wild-type allele is located in the vicinity of 4q35.1 and is approximately 6 kb in length. This allele, which encodes…

ING2 Gene

This gene plays a role in the modulation of both protein acetylation and apoptosis.

ING1 wt Allele

Human ING1 wild-type allele is located within 13q34 and is approximately 8 kb in length. This allele, which encodes inhibitor of growth…

ING1 Gene

This gene is involved in the regulation of both apoptosis and cell growth.

Infusion-Related Reaction

A reaction to the infusion of pharmacological or biological substances. Symptoms may appear within minutes to hours following the infusion and may…

Infusion Site Extravasation

Leakage of a pharmacologic or a biological substance from the infusion site into the surrounding tissue. Signs and symptoms include induration, erythema,…