Inherited bone marrow failure syndrome

Pronunciation

Definition 1

A rare disorder in which a person’s bone marrow is unable to make enough blood cells and there is a family history of the same disorder. There are several different types of inherited bone marrow failure syndrome, and patients with one of them are at high risk of forming acute leukemia or certain solid tumors. Also called IBMFS. (NCI Dictionary)

Definition 2

A group of inherited genetic hematopoietic stem cell disorders characterized by bone marrow failure that involves one or more cell lines. Representative examples include Fanconi anemia, Diamond-Blackfan anemia, and Shwachman-Diamond syndrome. (NCI Thesaurus)

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Inherited

Transmitted through genes that have been passed from parents to their offspring (children).

Inheritance Mode

The manner in which a particular genetic trait or disorder is passed from one generation to the next.

INHBB wt Allele

Human INHBB wild-type allele is located within 2cen-q13 and is approximately 6 kb in length. This allele, which encodes inhibin beta B…

INHBB Gene

This gene plays a role in the negative regulation of stromal cell proliferation in the gonads. It is also involved in cell…

INHBA wt Allele

Human INHBA wild-type allele is located within 7p15-p13 and is approximately 11 kb in length. This allele, which encodes inhibin beta A…

INHBA Gene

This gene is involved in the negative regulation of stromal cell proliferation in the gonads. It also plays a role in cell…