Health / Medical Topics

    Injectable Liposomal Suspension Dosage Form

    Definition 1

    A suspension composed of active and/or inert ingredient(s) encapsulated in liposomes and intended for injection. (NCI Thesaurus)

    Definition 2

    A liquid parenteral pharmaceutical dosage form structured as a multilamellar composition of concentric phospholipid spheres that encapsulate the drug (drug delivery systems) separated by layers of water. Drug release is facilitated and controlled by in vivo erosion of the liposomes. To further increase the in vivo circulation time, liposomes in some preparations are covalently derivatized with PEG to produce PEGylated or stealth liposomes. Covalent attachment of drugs to the outer surface of liposomes can potentially serve as a delayed-release product. (NCI Thesaurus/CDISC)




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