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Insulin-Like Growth Factor-Binding Protein 2
Definition 1
Encoded by human IGFBP2 Gene, cysteine-rich high molecular weight secreted 328-aa 35-kD Insulin-Like Growth Factor-Binding Protein 2 precursor contains an IGFBP domain and a thyroglobulin type-I domain. IGF-binding proteins prolong plasma IGF half-life and alter IGF interaction with cell surface receptors. The predominant form in plasma (150-kD) contains IGF-BP53 with apparent molecular mass of 53-kD. IGFBP2 binds IGF-II with high affinity more than IGF-I. (from LocusLink, Swiss-Prot, OMIM, and NCI) (NCI Thesaurus)
Definition 2
IGFBP2 contains a thyroglobulin type-I domain, belongs to the IGFBP family, and binds IGF-II more than IGF-I. IGFBPs display strong sequence homologies. IGFBPs contain three distinct domains. N-terminal domain 1 and C-terminal domain 3 contain invariant cysteine residues and are thought to be the IGF binding domains. Domain 2 generally lacks sequence identity among the IGFBPs. Domain 3 is homologous to the thyroglobulin type I repeat. IGF-I and IGF-II circulate in plasma tightly bound to IGFBPs. IGFs, IGFRs, and IGFBPs regulate cell proliferation and apoptosis; the primary effect of IGFBPs appears to be modulation of IGF activity and control of IGF-mediated cell growth and metabolism. Secreted IGF-binding proteins prolong the half-life of IGFs (somatomedins) and either inhibit or stimulate the growth promoting effects of IGFs; they alter the interaction of IGFs with cell surface receptors. (from OMIM 146731, SWISS-PROT P18065, and NCI) (NCI Thesaurus)
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