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Intercellular Adhesion Molecule 3
ICAM3 is a ligand for LFA-1, a major receptor of T-cells, B-cells, and granulocytes that mediates the leukocyte adhesion reactions underlying many immune functions. The interaction of LFA-1 with ICAM provides essential accessory adhesion signals in many immune interactions, including those between T- and B-lymphocytes and cytotoxic T-cells and their targets. ICAM3 is potentially the most important ligand for LFA-1 in the initiation of the immune response. ICAM3 is closely related to ICAM1, consists of five Ig domains, and binds LFA-1 through its two N-terminal domains. (from OMIM 146631 and NCI) (NCI Thesaurus)
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