| Health / Medical Topics |
Interferon-alpha Inducible Protein 10
A member of the alpha-chemokine family, IP10 is secreted from macrophages, endothelial cells, and keratinocytes in response to IFN-gamma and activates a G protein coupled receptor. IP10 has homology to PFIV, BTG, CTAP-III, and peptides associated with cell proliferation, is a potent inhibitor of angiogenesis, inhibits bone marrow colony formation, has anti-tumor activity, is a chemoattractant for monocytes and T-cells, promotes T-cell adhesion to endothelial cells, and probably participates in chronic cell-mediated inflammatory reactions. The IP10 gene is a RAS signaling target. (from OMIM 147310 and NCI) (NCI Thesaurus)
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