Interleukin-11

Pronunciation

Definition 1

One of a group of related proteins made by leukocytes (white blood cells) and other cells in the body. Interleukin-11 is made by support cells in the bone marrow. It causes the growth of several types of blood cells. Oprelvekin (interleukin-11 made in the laboratory) is used as a biological response modifier to increase the number of platelets, especially in patients receiving chemotherapy for cancer. Interleukin-11 is a type of cytokine. Also called IL-11. (NCI Dictionary)

Definition 2

Human interleukin-11 protein (199 aa, 21 kDa precursor) is encoded by the human interleukin-11 (IL11) gene. This protein stimulates T-cell-dependent development of immunoglobulin-producing B cells in antigen-specific antibody responses. It supports proliferation of both hematopoietic stem cells and megakaryocyte progenitor cells and regulates bone marrow adipogenesis. This protein also plays immunomodulatory roles in rheumatoid arthritis. (NCI Thesaurus)

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