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Interleukin-17
Definition 1
Interleukin 17 is a homodimer expressed in stimulated, but not resting, cytotoxic T-cells that induces stromal cells to produce pro-inflammatory and hematopoietic cytokines. IL17 enhances expression of IL6, IL8, and ICAM-1 in fibroblasts and appears to induce osteoclastogenesis and ODF, a membrane-associated protein essential to osteoclast differentiation. IL17 has sequence similarity to the herpesvirus saimiri immediate early gene 13 protein. (from OMIM 603149 and NCI) (NCI Thesaurus)
Definition 2
Interleukin-17, encoded by the IL17 gene, is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. (NCI Thesaurus/LocusLink)
Definition 3
Proinflammatory cytokine produced primarily by T-lymphocytes or their precursors. IL-17 is homologous to an open reading frame found in Herpesvirus saimiri. (NLM, Medical Subject Headings)
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