| Health / Medical Topics |
Interleukin-18
Definition 1
Cytokine which resembles IL-1 structurally and IL-12 functionally. It enhances the cytotoxic activity of NK cells and CTLs, and appears to play a role both as neuroimmunomodulator and in the induction of mucosal immunity. (NCI Thesaurus)
Definition 2
IL18 is a cytokine that resembles IL1 structurally and IL12 functionally. It is expressed in Kupffer cells and in activated macrophages and augments the cytotoxic activity of NK cells and CTLs. By increasing expression of vascular cell adhesion molecule 1, as well as adherence of melanoma cells to capillary endothelia, IL18 may promote development of hepatic metastases of melanoma. (from OMIM 600953 and NCI) (NCI Thesaurus)
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