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Interleukin-1 Receptor Alpha Type-I
Encoded by human IL1R1 Gene (IL1R Family), 569-aa 65-kDa (precursor) Interleukin-1 Receptor Alpha Type I is a type I membrane protein cytokine receptor for IL1A, IL1B, and IL1R1/IL1RA that binds to IL1RAP and contains 3 IgC2 domains and 1 TIR domain. An important mediator in many cytokine induced immune and inflammatory responses, agonist binding by IL1R1 leads to formation of a ternary signaling complex of IL1RAP/TOLLIP/MYD88/IRAK1 (or IRAK2) and NF-Kappa-B activation. (NCI Thesaurus)
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