| Health / Medical Topics |
Interleukin-1 Receptor-Associated Kinase 4
Widely expressed (strongest in kidney and liver) by human IRAK4 Gene, 460-aa Interleukin-1 Receptor-Associated Kinase 4 contains (like IRAK1, IRAK2, IRAKM, and Pelle) an N-terminal death domain and a central kinase domain. Similar to Pelle, IRAK4 has a short C-terminal domain. Like all IL1R-associated kinases, IRAK4 mediates Toll/IL1R family receptor signal transduction. Like IRAK1 and Pelle, IRAK4 has auto- and cross-phosphorylation activity. IRAK4 phosphorylates and activates IRAK1. It also interacts with MYD88 and TRAF6 and activates MAPK and NF kappa-B pathways. IRAK4 may act as an IRAK1 kinase, triggering phosphorylation cascades. (NCI Thesaurus)
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