Interleukin-4

Pronunciation

Definition 1

One of a group of related proteins made by leukocytes (white blood cells) and other cells in the body. Interleukin-4 is made by a type of T lymphocyte. It causes B lymphocytes to increase and to make antibodies and also increases the production of T lymphocytes. Interleukin-4 made in the laboratory is used as a biological response modifier to boost the immune system in cancer therapy. Interleukin-4 is a type of cytokine. Also called IL-4. (NCI Dictionary)

Definition 2

Human interleukin-4 protein (153 aa, 17.5 kDa precursor) is encoded by the human interleukin-4 (IL4) gene. Two isoforms of this protein are expressed by activated T cells. This protein is a pleiotropic soluble cytokine that is a ligand for the interleukin 4 receptor. This receptor-ligand interaction induces expression of MHC II and Fc receptors on B-cells, causing proliferation and differentiation of these cells. (NCI Thesaurus)

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