Interleukin-5

Pronunciation

Definition 1

One of a group of related proteins made by leukocytes (white blood cells) and other cells in the body. Interleukin-5 is made mainly by some T lymphocytes. It causes B lymphocytes to make more antibodies and increases the number of eosinophils. Interleukin-5 made in the laboratory is used as a biological response modifier to boost the immune system in cancer therapy. It is a type of cytokine. Also called IL-5. (NCI Dictionary)

Definition 2

Human interleukin-5 protein (134 aa, 15 kDa precursor) is encoded by the human interleukin-5 (IL5) gene. This cytokine acts as a growth and differentiation factor for eosinophils and induces terminal differentiation of B-cells which become Ig-secreting cells. It is thought to play a pivotal role in the pathogenesis of asthma. Elevated levels of this protein have been detected in both asthma and hypereosinophilic syndromes. (NCI Thesaurus)

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