Interleukin 6 Signal Transducer

Widely expressed (not restricted to IL6 responsive cells) by human IL6ST Gene (Type I Cytokine Receptor 2 Family), heterodimeric type I membrane protein (isoform 1) and secreted (isoform 2) Interleukin 6 Signal Transducer contains 5 fibronectin type III domains, an Ig-like C2-type domain, a BOX 1 motif required for JAK interaction/activation, and a WSXWS motif necessary for protein folding, intracellular transport, and cell-surface receptor binding. Part of cytokine receptor complexes, IL6ST is a signal transducer dependent on receptor binding for activation by many cytokines (IL6, CNTF, LIF, IL11, CT1, and OSM) that can utilize gp130 in signal transmission. IL6ST may regulate myocyte apoptosis and have a role in embryonic development. Isoform 2 is an autoantigen in rheumatoid arthritis but it is not specific to RA. (NCI Thesaurus)

YOU MAY ALSO LIKE

Interleukin 6 Measurement

The determination of the amount of interleukin 6 present in a sample.

Interleukin 5 Measurement

The determination of the amount of interleukin 5 present in a sample.

Interleukin 4 Receptor

IL4R when complexed with the common gamma chain (IL2RG) serves as the high-affinity interleukin 4 (IL4) receptor. It plays a major role…

Interleukin 4 Measurement

The determination of the amount of interleukin 4 present in a sample.

Interleukin 33 Measurement

The determination of the amount of interleukin 33 present in a sample.

Interleukin 32 Measurement

The determination of the amount of interleukin 32 present in a sample.