Intrabiliary Route of Administration

Definition 1

Administration within the biliary system for selective delivery of the agent to targeted hepatobiliary tissues and cell types, the goal of which is utilization of optimal therapeutic dosages combined with a reduction in systemic toxicity. Strategies for improving the tissue specificity include the use of tissue-specific ligands and the focal administration of drugs. Focal delivery has been primarily directed at uptake by the hepatocyte basolateral membrane and has included direct intraparenchymal injection, portal venous infusion, hepatic arterial infusion, and surgical systems for temporarily isolating the liver from the vasculature. (NCI Thesaurus)

Definition 2

Administration within the bile, bile ducts or gallbladder. (Food and Drug Administration/CDISC)

YOU MAY ALSO LIKE

Intraarticular Route of Administration

Administration of the drug within a joint.

Intraarterial Route of Administration

Intraarterial drug injection or infusion is a method of delivering a drug directly into artery or arteries to localize its effect to…

Intraamniotic Route of Administration

Administration of the drug within the amnion.

Intraabdominal Route of Administration

Administration of the drug within the abdominal cavity, typically as a loco-regional therapy for disease confined to the abdomen.

Intra-Atrial Conduction Delay by ECG Finding

An electrocardiographic finding of a delay in impulse propagation through the atria. This is characterized by broad P waves which are often…

Intra-arterial brachytherapy

A type of radiation therapy used to treat liver cancer that is advanced or has come back. Tiny beads that hold the…