Iobenguane Sulfate I-123

Definition 1

The sulfate salt form of iobenguane, an iodine-123 labeled aralkylguanidine norepinephrine analogue used as a diagnostic imaging tracer. Iobenguane is structurally related to guanethidine and norepinephrine. This agent, functioning as a false substrate of norepinephrine, is taken up and localized in the granules of pre-synaptic adrenergic neurons, thus making this compound useful for the imaging of neuroendocrine tissues and tumors. (NCI Thesaurus)

Definition 2

The neurotransmitter analogue 3-nitrobenzylguanidine conjugated to iodine I 123 and used as a gamma-emitting imaging agent. The adrenergic tissue uptake and storage of I-123 metaiodobenzylguanidine (I-123 MIBG) mimics that of norepinephrine (NE). The distribution of this agent enables the scintigraphic imaging of neural crest tumors, such as neuroblastoma and pheochromocytoma. (NCI Thesaurus)

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