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ISIS 3521
Definition 1
A substance that is being studied in the treatment of cancer. (NCI Dictionary)
Definition 2
A synthetic phosphorothioate oligodeoxynucleotide. As an antisense molecule, ISIS 3521 hybridizes to the 3-untranslated region of the human protein kinase C (PKC-alpha) mRNA, thereby inhibiting PKC-alpha expression and growth of PKC-alpha-dependent tumor cells. (NCI Thesaurus)
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A substance that is being studied in the treatment of cancer.
Marked fibrosis with cirrhosis is present.
Marked bridging fibrosis with formation of occasional hepatic nodules is present.
Marked bridging fibrosis (portal to portal and porto-central) is present.
Fibrosis extends beyond the portal areas. Occasional portal to portal bridging fibrosis is present.
Minimal fibrosis in most portal areas.
