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ISIS 5132
Definition 1
A substance that is being studied in the treatment of cancer. (NCI Dictionary)
Definition 2
A synthetic, 20-base antisense oligodeoxynucleotide that hybridizes to c-raf kinase messenger RNA. ISIS 5132 has been shown to specifically suppress Raf-1 expression both in vitro and in vivo. Raf-1 serine/threonine kinase functions as a critical effector of Ras-mediated signal transduction; constitutive activation of this pathway directly contributes to malignant transformation. (NCI Thesaurus)
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A substance that is being studied in the treatment of cancer.
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Marked fibrosis with cirrhosis is present.
Marked bridging fibrosis with formation of occasional hepatic nodules is present.
Marked bridging fibrosis (portal to portal and porto-central) is present.
Fibrosis extends beyond the portal areas. Occasional portal to portal bridging fibrosis is present.
