ITP

A condition in which platelets (blood cells that cause blood clots to form) are destroyed by the immune system. The low platelet count causes easy bruising and bleeding, which may be seen as purple areas in the skin, mucous membranes, and outer linings of organs. Also called idiopathic thrombocytopenic purpura and immune thrombocytopenic purpura. (NCI Dictionary)

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ITK wt Allele

Human ITK wild-type allele is located within 5q31-q32 and is approximately 74 kb in length. This allele, which encodes tyrosine-protein kinase ITK/TSK…

ITK Gene

This gene is involved in the differentiation and proliferation of T cells.

ITIM

ITIM (immunoreceptor Tyr-based inhibition motif) (I/V-X-Y-X-X-L), a protein domain involved in STP, binds to SH2 domain in SHP1 and SHP2, e.g., in…

ITGB7 wt Allele

Human ITGB7 wild-type allele is located in the vicinity of 12q13.13 and is approximately 16 kb in length. This allele, which encodes…