JAK3 wt Allele

Human JAK3 wild-type allele is located in the vicinity of 19p13.1 and is approximately 22 kb in length. This allele, which encodes tyrosine-protein kinase JAK3 protein, plays a role in signal transduction in the interleukin-2 and interleukin-4 signaling pathways. Mutations in the JAK3 gene which abolish the tyrosine-protein kinase activity of its protein product cause autosomal severe combined immunodeficiency disease. (NCI Thesaurus)

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JAK3 Gene

This gene plays a role in signal transduction.

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JAK2 wt Allele

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A variation in the amino acid sequence for the tyrosine-protein kinase JAK2 protein.

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