JAW1-Related Protein

The gene encoding this protein is similar to a mouse putative tumor suppressor gene that is frequently disrupted by mouse AIDS-related virus (MRV). The protein, which is found in the membrane of the endoplasmic reticulum, is similar to Jaw1, a lymphoid-restricted protein whose expression is downregulated during myeloid differentiation. Therefore, this gene may be a myeloid leukemia tumor suppressor gene. This protein is an inositol 1,4,5-triphosphate-associated cGMP kinase substrate. Calcium release from the endoplasmic reticulum controls a number of cellular processes, including proliferation and contraction of smooth muscle and other cells and contributes to the antiproliferative and proapoptotic effects of nitric oxide and cGMP. (from LocusLink and OMIM) (NCI Thesaurus)

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The joint between the head of the lower mandible and the temporal bone.

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Fractures of the upper or lower jaw.

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A device designed to use opposing parts to close on and hold an object.

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Noise in the temporomandibular joint, with or without pain, when fully opening the jaw.

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The bones of the skull that frame the mouth and serve to open it; the bones that hold the teeth.