Kit ligand

Pronunciation

Definition 1

A substance that causes blood stem cells (cells from which other types of cells develop) to change into different types of blood cells and increases the number and actions of these cells in the blood. Kit ligand is a type of cytokine and a type of growth factor. Also called SCF and stem cell factor. (NCI Dictionary)

Definition 2

Stem Cell Factor is a hematopoietic growth factor, a key signal in mast cell differentiation and function, and a ligand for the KIT tyrosine kinase receptor CD117. In the mouse, this growth factor is encoded by Sl ('steel'), a gene critical to the development of several cell lineages as well as to hematopoiesis in the adult. SCF augments proliferation of myeloid and lymphoid progenitors. (from OMIM 184745 and NCI) (NCI Thesaurus)

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A molecular genetic abnormality indicating the presence of a mutation in exon 9 of the KIT gene located within 4q11-q12.

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A molecular genetic abnormality indicating the presence of a mutation in exon 13 of the KIT gene located within 4q11-q12.

KIT Exon 11 Mutation

A molecular genetic abnormality indicating the presence of a mutation in exon 11 of the KIT gene located within 4q11-q12.

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A dosing unit equal to the amount of active ingredient(s) contained in a kit.