| Health / Medical Topics |
Lamin B1
Lamin B1, one of the two B type proteins, is encoded by the human LMNB1 gene. Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. The lamin family of proteins are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. (from LocusLink and Swiss-Prot) (NCI Thesaurus)
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