Langerhans cell histiocytosis

Pronunciation

Definition 1

A group of rare disorders in which too many Langerhans cells (a type of white blood cell) grow in certain tissues and organs including the bones, skin, and lungs, and damage them. Langerhans cell histiocytosis may also affect the pituitary gland (which makes hormones that control other glands and many body functions, especially growth). Langerhans cell histiocytosis is most common in children and young adults. Also called LCH. (NCI Dictionary)

Definition 2

A neoplastic proliferation of Langerhans cells which contain Birbeck granules by ultrastructural examination. Three major overlapping syndromes are recognized: eosinophilic granuloma, Letterer-Siwe disease, and Hand-Schuller-Christian disease. The clinical course is generally related to the number of organs affected at presentation. (NCI Thesaurus/WHO)

YOU MAY ALSO LIKE

Langerhans Cell

Dendritic clear cells in the epidermis, containing distinctive granules that appear rod- or racket-shaped in section, but lacking tonofilaments, melanosomes, and desmosomes;…

Lane

A defined path with physical dimensions through which an object or substance may traverse.

Landrace Pig

Developed in Denmark by crossing native pigs with the Large White pig breed. The Landrace pig was imported into the UK in…

Landau-Kleffner Syndrome

A rare childhood syndrome characterized by the progressive or sudden inability to understand and use spoken language (aphasia) and paroxysmal electrical brain…

Lampyridae

A beetle in the family Lampyridae noted for its bioluminescence. The organism from which luciferase was first isolated.

LAMP3 wt Allele

Human LAMP3 wild-type allele is located within 3q26.3-q27 and is approximately 41 kb in length. This allele, which encodes lysosome-associated membrane glycoprotein…