Lansoprazole

Pronunciation

Definition 1

A drug that reduces the amount of acid made in the stomach. It is used to treat stomach ulcers, gastroesophageal reflux disease (a condition in which acid from the stomach causes heartburn), and conditions in which the stomach makes too much acid. Lansoprazole is a type of proton pump inhibitor (PPI). Also called Prevacid. (NCI Dictionary)

Definition 2

A substituted benzimidazole prodrug with selective and irreversible proton pump inhibitor activity. Lansoprazole prodrug is converted to an active sulfonamide derivative in the acidic environment of the gastric parietal cell; the sulfonamide derivative binds to the gastric proton pump H+/K+ ATPase and forms a stable disulfide bond with the sulfhydryl group near the potassium-binding site on the luminal side, resulting in inactivation of the ATPase and a reduction in gastric acid secretion. This agent does not have anticholinergic or histamine H2 -receptor antagonistic properties. (NCI Thesaurus)

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