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LDL CHOLESTEROL
| Pronunciation (US): |  | (GB): | |
I. (noun)
Sense 1
Meaning:
The cholesterol in low-density lipoproteins; the 'bad' cholesterol; a high level in the blood is thought to be related to various pathogenic conditions
Classified under:
Hypernyms ("LDL cholesterol" is a kind of...):
cholesterin; cholesterol (an animal sterol that is normally synthesized by the liver; the most abundant steroid in animal tissues)
Hyponyms (each of the following is a kind of "LDL cholesterol"):
oxidized LDL cholesterol (LDL cholesterol that has been bombarded by free radicals; it is thought to cause atherosclerosis)
Holonyms ("LDL cholesterol" is a substance of...):
beta-lipoprotein; LDL; low-density lipoprotein (a lipoprotein that transports cholesterol in the blood; composed of moderate amount of protein and a large amount of cholesterol; high levels are thought to be associated with increased risk of coronary heart disease and atherosclerosis)
Context examples:
This agent functions as an estrogen agonist in lipid metabolism, thereby decreasing total and LDL cholesterol levels.
(Acolbifene hydrochloride, NCI Thesaurus)
The data included measurements of each participant's LDL cholesterol, high-density lipoprotein (HDL) cholesterol, and triglyceride levels at the beginning of the study.
(Low Levels of Bad Cholesterol Increase Stroke Risk, The Titi Tudorancea Bulletin)
The consequence is less LDL receptor in the liver, higher LDL cholesterol in the blood and an increased risk of blood clots in the heart.
(Discovery Can Pave the Way for More Effective Cholesterol Medicine, The Titi Tudorancea Bulletin)
The determination of the ratio of HDL cholesterol compared to LDL cholesterol present in a sample.
(HDL Cholesterol to LDL Cholesterol Ratio Measurement, NCI Thesaurus)
Overall, fenofibrate reduces total cholesterol, LDL cholesterol, apolipoprotein B, total triglycerides and triglyceride rich lipoprotein (VLDL) while increasing HDL cholesterol.
(Fenofibrate, NCI Thesaurus)
Treatment with nicanartine both decreases plasma LDL cholesterol and increases plasma HDL cholesterol.
(Nicanartine, NCI Thesaurus)
Binding of SREBPs to the LDL receptor promoter increases the expression of LDL receptor on the cell surface and increases the internalization of LDL from plasma, increasing cellular cholesterol levels and lowering LDL cholesterol in the plasma.
(Lipid Synthesis Pathway, NCI Thesaurus/BIOCARTA)
The scientists noted that several of the genetic differences in the Inuit were associated with other characteristics, including a lower height and weight and lower levels of fasting insulin and LDL cholesterol levels, which could potentially protect against heart disease and diabetes.
(Genetic Adaptations to Diet and Climate, NIH)
Compared to the control group, the calorie restriction group experienced significant improvements in multiple cardiometabolic risk factors, including waist circumference, blood pressure, HDL cholesterol, LDL cholesterol, triglycerides, insulin sensitivity and fasting glucose, and C-reactive protein (a marker of systemic inflammation associated with multiple chronic conditions and diseases of age).
(Moderate calorie restriction in young and middle-aged adults significantly reduces heart and metabolic risk factors independent of weight loss, National Institutes of Health)
New research from Aarhus University has now uncovered the way in which PCSK9 breaks down the LDL receptors, which are a kind of receptor molecule that absorbs the bad LDL cholesterol in the blood into the liver.
(Discovery Can Pave the Way for More Effective Cholesterol Medicine, The Titi Tudorancea Bulletin)
