LEFTY2 wt Allele

Human LEFTY2 wild-type allele is located in the vicinity of 1q42.1 and is approximately 5 kb in length. This allele, which encodes transforming growth factor beta-4 protein, plays a role in the left-right asymmetry determination of organ systems during development and is also involved in endometrial bleeding regulation. Mutations in this gene produce variant alleles that are associated with left-right axis malformations, particularly in the heart and lungs. Further, certain types of infertility have been associated with aberrant allelic expression in the endometrium. (NCI Thesaurus)

YOU MAY ALSO LIKE

LEFTY2 Gene

This gene is involved in embryogenesis and morphogenesis. It plays a role in the determination of left-right asymmetry.

LEFTY1 wt Allele

Human LEFTY1 wild-type allele is located in the vicinity of 1q42.1 and is approximately 3 kb in length. This allele, which encodes…

LEFTY1 Gene

This gene is involved in left-right asymmetry determination of organ systems during development.

Left-Right Determination Factor B

Containing a TGF-beta family domain, similar to LEFTYA, and encoded by human LEFTB Gene (TGF-Beta Family), secreted 366-amino acid 41-kD Left-Right Determination…

Left Ventricular Systolic Dysfunction Adverse Event

Defined in terms of ejection fraction, a good clinical indicator of ventricular systolic function. Normal ejection fraction is 0.50 or more…

Left Ventricular Systolic Dysfunction

The degree of impairment of the left cardiac ventricle to contract efficiently.