| Health / Medical Topics |
Letterer-Siwe Disease
Definition 1
A multifocal, multisystem form of Langerhans-cell histiocytosis. There is involvement of multiple organ systems including the bones, skin, liver, spleen, and lymph nodes. Patients are usually infants presenting with fever, hepatosplenomegaly, lymphadenopathy, bone and skin lesions, and pancytopenia. (NCI Thesaurus)
Definition 2
Acute, disseminated, rapidly progressive form of Langerhans-cell histiocytosis. (NLM, Medical Subject Headings)
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