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Leukoencephalopathy
Definition 1
White matter changes first described in children with leukemia, associated with radiation and chemotherapy injury, often associated with methotrexate; pathologically characterised by diffuse reactive astrocytosis with multiple areas of necrotic foci without inflammation. (NCI Thesaurus)
Definition 2
A disorder characterized by diffuse reactive astrocytosis with multiple areas of necrotic foci without inflammation. (NCI Thesaurus/CTCAE)
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