Liarozole Fumarate

The orally active fumarate salt of the benzimidazole derivative liarozole with potential antineoplastic activity. As a retinoic acid metabolism blocking agent (RAMBA), liarozole inhibits cytochrome P450-dependent all-trans-retinoic acid (ATRA)-4-hydroxylase, resulting in an increase in endogenous ATRA production, inhibition of cell proliferation, and induction of cell differentiation. This agent also inhibits aromatase, the enzyme that catalyzes the final, rate-limiting step in estrogen biosynthesis. (NCI Thesaurus)

YOU MAY ALSO LIKE

Liarozole

An anticancer drug that promotes differentiation by increasing the levels of retinoic acid within the tumor.

Li-Fraumeni syndrome

A rare, inherited predisposition to multiple cancers, caused by an alteration in the p53 tumor suppressor gene.

LHX4/IGHG1 Fusion Gene

A fusion gene that results from a chromosomal translocation t(1;14)(q25;q32) which places the LHX4 gene on the 5' side of the coding…

LHX4 wt Allele

Human LHX4 wild-type allele is located in the vicinity of 1q25.2 and is approximately 45 kb in length. This allele, which encodes…

LHX4 Gene

This gene plays a role in both transcription and pituitary differentiation.

LHX3 wt Allele

Human LHX3 wild-type allele is located in the vicinity of 9q34.3 and is approximately 9 kb in length. This allele, which encodes…