Ligand-Independent Ion Channel Activation

A process that involves interactions between an intrinsic membrane molecule and an electrochemical gradient across a membrane, often a voltage or a pH gradient. Such interactions may activate or deactivate an ion channel in the membrane, and constitute the basis of nerve conduction of impulse. (NCI Thesaurus)

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General term for proteins that have binding as a major function.

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Ligand

An ion, molecule or molecular group that binds to a substance to form a larger complex.