Liposome-encapsulated doxorubicin citrate

Pronunciation

Definition 1

A form of the anticancer drug doxorubicin citrate that is contained inside very tiny, fat-like particles. It is being studied in the treatment of breast cancer that has spread and in the treatment of other types of cancer. Doxorubicin citrate damages DNA and may kill cancer cells. Liposomal-encapsulated doxorubicin citrate may have fewer side effects and may work better than doxorubicin citrate. (NCI Dictionary)

Definition 2

A formulation of the citrate salt of the antineoplastic anthracycline antibiotic doxorubicin, encapsulated within liposomes, with antitumor activity. Doxorubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and RNA synthesis. This agent also interacts with cell membrane lipids causing lipid peroxidation. Liposomal delivery of doxorubicin improves drug penetration into tumors and decreases drug clearance, thereby increasing the duration of therapeutic drug effects while lowering the toxicity profile. (NCI Thesaurus)

YOU MAY ALSO LIKE

Liposome Vesicle

A microscopic vesicle consisting of one or more phospholipid layers surrounding an aqueous core. Liposomes can be utilized to facilitate the delivery…

Liposome

A type of nanoparticle made of lipids, or fat molecules, surrounding a water core. Liposomes, several of which are widely used to…

Liposomal Vinorelbine

A formulation of the semisynthetic vinca alkaloid, vinorelbine, encapsulated within liposomes, with antineoplastic activity. Vinorelbine binds to tubulin and prevents formation of…

Liposomal vincristine sulfate

A form of the anticancer drug vincristine sulfate that is contained inside very tiny, fat-like particles. It may have fewer side effects…

liposomal SN-38

A form of the anticancer drug irinotecan that is contained in very tiny, fat-like particles. It may have fewer side effects and…

Liposomal Rhenium Re 186

A therapeutic preparation consisting of the beta-emitting radioisotope rhenium Re 186 encapsulated in a nanoliposome, with potential antineoplastic activity. Upon intratumoral infusion…