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liposome-encapsulated irinotecan hydrochloride PEP02
Pronunciation
Definition 1
A form of the anticancer drug irinotecan hydrochloride that is contained inside very tiny, fat-like particles. It is being studied in the treatment of colorectal cancer that has spread to other parts of the body and in other types of cancer. Irinotecan hydrochloride blocks cell division and DNA repair, and it may kill cancer cells. Liposome-encapsulated irinotecan hydrochloride PEP02 may have fewer side effects and work better than irinotecan hydrochloride. It is a type of topoisomerase inhibitor and a type of camptothecin analog. Also called PEP02. (NCI Dictionary)
Definition 2
A liposomal formulation of the hydrochloride salt of the semisynthetic camptothecin analogue irinotecan with potential antineoplastic activity. During the S phase of the cell cycle, irinotecan selectively stabilizes topoisomerase I-DNA covalent complexes, inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing lethal double-strand DNA breaks when complexes are encountered by the DNA replication machinery. Liposome encapsulation of this agent promotes efficient drug delivery into the cytosol from the endosome compartment of the cell. (NCI Thesaurus)
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