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LMB-7 immunotoxin
Pronunciation
Definition 1
A toxic substance linked to an antibody that attaches to tumor cells and kills them. (NCI Dictionary)
Definition 2
A single chain chimeric protein consisting of a monoclonal antibody fragment attached to a portion of the Pseudomonas exotoxin A. LMB-7 immunotoxin attaches to B3, a Lewis Y-related carbohydrate epitope on some solid tumor cells. The antibody attaches to the cell and the exotoxin inhibits protein synthesis by inactivating elongation factor 2. (NCI Thesaurus)
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