Health / Medical Topics

    LMB-9 immunotoxin

    Pronunciation

    Definition 1

    A toxic substance linked to an antibody that attaches to tumor cells and kills them. (NCI Dictionary)

    Definition 2

    A recombinant disulfide stabilized anti-Lewis Y IgG immunotoxin containing a 38 KD toxic element derived from the Pseudomonas aeruginosa exotoxin A and a monoclonal antibody fragment, designed to target adenocarcinomas expressing Lewis Y. LMB-9 immunotoxin attaches to tumor cells, facilitating he entry of the exotoxin. The exotoxin moiety induces caspase-mediated apoptosis of tumor cells via a mechanism involving mitochondrial damage; it also catalyzes the transfer of ADP ribose from nicotinamide adenine dinucleotide (NAD) to elongation factor-2 in eukaryotic cells, thereby inactivating elongation factor 2 and inhibiting protein synthesis. (NCI Thesaurus)




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    A toxic substance linked to an antibody that attaches to tumor cells and kills them.
    A toxic substance linked to an antibody that attaches to tumor cells and kills them.
    A toxic substance linked to an antibody that attaches to tumor cells and kills them.

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