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Lodenosine
Definition 1
A synthetic purine fluoro-dideoxyadenosine derivative, antiviral Lodenosine acts as a reverse transcriptase inhibitor. Although used in clinical trials for treatment of human immunodeficiency (HIV), Lodenosine induces liver or kidney damage and its use has been reconsidered. (NCI Thesaurus)
Definition 2
A nucleoside reverse transcriptase inhibitor analog of adenosine. Lodenosine is a synthetic purine fluoro-dideoxyadenosine derivative that was rationally designed to have improved chemical and enzymatic stability. It has shown activity against clinical isolates and cell lines that are resistant to AZT, dideoxyinosine, and dideoxycytosine. (NCI Thesaurus)
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