Low Grade Mouse MIN

A focal atypical, non-invasive epithelial lesion with minimal atypia and low malignant potential. Atypical hyperplasia, DIN and certain grades of DCIS are considered human homologs. Focal increase of epithelium that contains cells with atypical nuclei. Limited to focal lesions with mild to moderate cytological atypia. When transplanted, the foci grow in gland cleared mammary fat pads but not in the subcutaneous tissue. Low grade lesions seldom undergo malignant transformation and do not metastasize. Mammary Intraepithelial Neoplasia (MIN) has been proposed by the Annapolis Pathology Panel as the preferred term. It is considered the mouse counterpart or synonym for Atypical Hyperplasia, DIN in the human breast. Some pathologists believe that these proliferations are premalignant. Nuclear atypia corresponds to a nuclear score of one in the Elston-Ellis grading system. (NCI Thesaurus/MMHCC)

YOU MAY ALSO LIKE

Low Grade Lymphoma

A type of lymphoma that tends to grow and spread slowly, and has few symptoms. Also called indolent lymphoma.

Low Grade Lung Neuroendocrine Neoplasm

A low grade malignant neoplasm with neuroendocrine differentiation that arises from the lung. This category includes typical carcinoid tumor.

Low Grade Liver Dysplastic Nodule

A hepatic dysplastic nodule characterized by the presence of low grade atypical cellular changes.

Low Grade Intraepithelial Neoplasia

A precancerous neoplastic process that affects the squamous, glandular, or transitional cell epithelium without evidence of invasion. It is characterized by the…

Low Grade Gastric Intraepithelial Neoplasia

A gastric intraepithelial lesion characterized by the presence of neoplastic cells with mild cytologic atypia, mild architectural changes, and low number of…

Low Grade Flat Villous Dysplasia of the Mouse Intestinal Tract

Branching or elongation of crypts with some reduction of interglandular stroma containing cells with low nuclear to cytoplasm ratio. Cell nuclei are…