Loxoribine

A guanine ribonucleotide derivative with immunostimulatory and immunomodulatory activity. Loxoribine undergoes facilitated transport across the plasma membrane into the cytoplasmic compartment of the cell and acts intracellularly, bypassing the biochemical steps involved in the membrane signal transduction pathway used by Ag or anti-IgM Abs to activate B cells. This agent activates the Toll-like receptor 7 (TLR7), a member of the TLR family of pathogen-associated molecular pattern recognition receptors thereby activating the innate immune system. This activation requires endosomal maturation and recognition is restricted to TLR7. As a result, loxoribine induces cycling B cells to proliferate and differentiate non-specifically and recruit antigen-reactive B cells to undergo differentiation to antibody production, markedly amplifying the underlying response in the process. (NCI Thesaurus)

YOU MAY ALSO LIKE

LOXO-101

A substance that blocks a protein called Trk, which is involved in cell signaling and growth. Trk may be found in a…

LOXL2 wt Allele

Human LOXL2 wild-type allele is located in the vicinity of 8p21.3 and is approximately 107 kb in length. This allele, which encodes…

LOXL2 Gene

This gene is involved in protein crosslinking.

Loxapine Succinate

The succinate salt form of loxapine, a tricyclic dibenzoxazepine antipsychotic agent with antiemetic, sedative, anticholinergic, and antiadrenergic actions. Loxapine succinate exerts its…

LOX wt Allele

Human LOX wild-type allele is located in the vicinity of 5q23.2 and is approximately 12 kb in length. This allele, which encodes…

LOX Gene

This gene plays a role in cross-linking extracellular matrix proteins.