Lyophilized Black Raspberry Lozenge

A lozenge containing lyophilized black raspberry with potential antioxidant, pro-apoptotic, anti-angiogenic and chemopreventive activities. In addition to vitamins, minerals and phytosterols, black raspberries are rich in phenolic acids, such as gallic acid, ellagic acid, proanthocyanidins, and flavonoids. The anthocyanins appear to contribute significantly to this agent's effects. Anthocyanins inhibit both the activation of several signal transduction pathways, including the mitogen-activated protein kinase-mediated pathways, and certain transcription factors, such as nuclear factor kappa B (NF-kB), activator protein-1 (AP-1) complex, and nuclear factor in activated T-cells (NFAT). This inhibitory activity modulates the expression of downstream target genes that are upregulated in a variety of cancer cell types, including inducible nitric oxide synthase, cyclooxygenase-2, vascular endothelial growth factor and the anti-apoptotic protein survivin. (NCI Thesaurus)

YOU MAY ALSO LIKE

Lynparza

A drug used to treat advanced ovarian cancer caused by mutations (changes) in the BRCA1 and BRCA2 genes. It is used in…

Lynch syndrome

An inherited disorder in which affected individuals have a higher-than-normal chance of developing colorectal cancer and certain other types of cancer, often…

Lynch 2 Syndrome

A rare genetic neoplastic syndrome with an autosomal dominant pattern of inheritance but incomplete penetrance. It is associated with an inherited risk…

Lynch 1 Syndrome

A rare genetic neoplastic syndrome with an autosomal dominant pattern of inheritance but incomplete penetrance. It is associated with a greater than…

LYN wt Allele

Human LYN wild-type allele is located within 8q13 and is approximately 132 kb in length. This allele, which encodes tyrosine-protein kinase Lyn…

LYN Gene

This gene plays a role in signal transduction.