| Health / Medical Topics |
MAD/MXI1
MAD and MXI1 bZIP proteins belong to a subfamily of MAX-interacting proteins. MAX interacts with MYC via bZIP interaction domains and MAX binding is essential for MYC activity; MYC homodimers are inactive. MAD/MAX and MXI1/MAX heterodimers form a DNA-binding complex similar to MYC/MAX. MAD and MXI1 act as transcriptional repressors and appear to antagonize MYC by competing for MAX, and for DNA binding sites, and recruit SIN3 proteins and their associated co-repressors. (from OMIM 600021, 600020, and NCI) (NCI Thesaurus)
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