Making higher energy light to fight cancer

Scientists at the University of California, Riverside and The University of Texas at Austin have demonstrated that it’s possible to achieve photon up-conversion, the emission of higher energy light, when using carefully designed structures containing silicon nanocrystals and specialized organic molecules.

Silicon quantum dots convert a green, lower-energy laser light into a higher-energy blue light. Photo: Lorenzo Mangolini & Ming Lee Tang/UCR

The discovery brings scientists one step closer to developing minimally invasive photodynamic treatments for cancer.

The advance could also hasten new technologies for solar-energy conversion, quantum information, and near-infrared driven photocatalysis.

High energy light, like ultraviolet laser light, can form free radicals able to attack cancer tissue.

Ultraviolet light, however, doesn't travel far enough into tissues to generate therapeutic radicals close to the tumor. Near-infrared light penetrates deeply but doesn't have enough energy to generate the radicals.

While photon up-conversion can overcome this limitation, up-converted materials have low efficiency or high toxicity.

Silicon is known for being nontoxic, but researchers had not been able to demonstrate that silicon nanocrystals can up-convert photons, leaving this promising cancer treatment tantalizingly out of reach.

Scientists attacked this problem by studying the surface chemistry of silicon nanocrystals. The team learned to attach ligands, which help bind molecules together, to a nanoparticle.

The ligands are designed to transfer the energy from the nanocrystals to surrounding molecules.

The scientists then shined laser light into a solution. They found that silicon nanocrystals with appropriate surface ligands can rapidly transfer energy to surrounding molecules. (National Science Foundation)

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