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Malignant Leydig Cell Tumor
Definition 1
A Leydig cell tumor characterized by large tumor size, the presence of cytologic atypia, increased mitotic activity, necrosis, and vascular invasion. Approximately 10% of the testicular Leydig cell tumors show malignant characteristics and metastasize. Leydig cell tumors of the ovary follow a benign clinical course. (NCI Thesaurus)
Definition 2
A malignant neoplasm of the testis originating from interstitial (Leydig) cells. (NCI Thesaurus/CDISC)
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