| Health / Medical Topics |
Marizomib
A naturally-occurring salinosporamide, isolated from the marine actinomycete Salinospora tropica, with potential antineoplastic activity. Marizomib irreversibly binds to and inhibits the 20S catalytic core subunit of the proteasome by covalently modifying its active site threonine residues; inhibition of ubiquitin-proteasome mediated proteolysis results in an accumulation of poly-ubiquitinated proteins, which may result in the disruption of cellular processes, cell cycle arrest, the induction of apoptosis, and the inhibition of tumor growth and angiogenesis. This agent more may more potent and selective than the proteasome inhibitor bortezomib. (NCI Thesaurus)
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A coded value specifying a domestic partnership status.
A demographic parameter indicating a person's current conjugal status.
Any substance or product derived from any organism that lives in bodies of fresh or salt water.
Any organism that lives in the sea
The study of organisms that live in the sea or in other bodies of water.
An anticancer drug that belongs to the family of drugs called angiogenesis inhibitors. Marimastat is a matrix metalloproteinase inhibitor.
