Medicine
Symptomatic; altered GI function (e.g., altered dietary habits, diarrhea, or GI fluid loss); IV fluids indicated <24 hrs »
Symptomatic and medical intervention or minor cauterization indicated »
Patchy ulcerations or pseudomembranes »
Upper aerodigestive tract sites: Symptomatic but can eat and swallow modified diet; respiratory symptoms interfering with function but not interfering with ADL… »
Partial resection of injured organ/structure indicated »
Localized, local intervention indicated »
Localized, local intervention indicated »
Localized, local intervention indicated »
Moderate pain; pain or analgesics interfering with function, but not interfering with ADL »
Symptomatic, tube thoracostomy or medical management indicated; associated with altered respiratory function but not interfering with ADL »
Partial resection of injured organ/structure indicated »
Moderate pain; pain or analgesics interfering with function, but not interfering with ADL »
Decrease in orgasmic response requiring intervention »
BMD t-score < -2.5; loss of height <2 cm; anti-osteoporotic therapy indicated »
Partial resection of injured organ/structure indicated »
Symptomatic (e.g., claudication); not interfering with ADL; repair or revision not indicated »
Symptomatic (e.g., claudication); not interfering with ADL; repair or revision not indicated »
Symptomatic and interfering with function, but not interfering with ADL »
Moderate pain; pain or analgesics interfering with function, but not interfering with ADL »
External otitis with moist desquamation, edema, enhanced cerumen or discharge; tympanic membrane perforation; tympanostomy »
Serous otitis, medical intervention indicated »
Partial resection of injured organ/structure indicated »
Partial resection of injured organ/structure indicated »
Gross bleeding, medical intervention, or urinary tract irrigation indicated »
Partial resection of injured organ/structure indicated »
Symptomatic, associated with altered renal/GU function »
Moderate pain; pain or analgesics interfering with function, but not interfering with ADL »
Moderate pain; pain or analgesics interfering with function, but not interfering with ADL »
Present with associated symptoms (e.g., lightheadedness, shortness of breath) »
Increase in stool frequency, bulk, or odor; steatorrhea »
Symptomatic; altered GI function (e.g., altered dietary habits, diarrhea, or GI fluid loss); IV fluids indicated <24 hrs »
Symptomatic and medical intervention or minor cauterization indicated »
Localized, local intervention indicated »
Localized, local intervention indicated »
Localized, local intervention indicated »
Partial resection of injured organ/structure indicated »
Symptomatic; medical intervention indicated »
Symptomatic; altered GI function (e.g., altered dietary habits, vomiting, bleeding, diarrhea); IV fluids indicated <24 hrs »
Partial resection of injured organ/structure indicated »
Symptomatic; dietary modification or oral agent indicated »
Symptomatic, medical intervention indicated »
Localized, local intervention indicated »
Localized, local intervention indicated »
Localized, local intervention indicated »
Symptomatic; intervention indicated »
Partial resection of injured organ/structure indicated »
Partial resection of injured organ/structure indicated »
1.5 - 2 x ULN »
Symptomatic and interfering with function, but not interfering with ADL »
Local wound care; medical intervention indicated »
Localized, local intervention indicated »
CTCAE Grade 2 Pelvis Infection NOS with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils
Localized, local intervention indicated »
Localized, local intervention indicated »
Partial resection of injured organ/structure indicated »
Moderate pain; pain or analgesics interfering with function, but not interfering with ADL »
Localized, local intervention indicated »
Localized, local intervention indicated »
Localized, local intervention indicated »
Partial resection of injured organ/structure indicated »
Moderate pain; pain or analgesics interfering with function, but not interfering with ADL »
Symptomatic pericarditis (e.g., chest pain) »
Moderate pain; pain or analgesics interfering with function, but not interfering with ADL »
Moderate pain; pain or analgesics interfering with function, but not interfering with ADL »
Moderate gingival recession or gingivitis; multiple sites of bleeding on probing; moderate bone loss »
Brief (<24 hrs) episode of ischemia managed non-surgically and without permanent deficit »
Partial resection of injured organ/structure indicated »
Localized, local intervention indicated »
Localized, local intervention indicated »
Localized, local intervention indicated »
Partial resection of injured organ/structure indicated »
Localized, local intervention indicated »
CTCAE Grade 2 Peristomal Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils
Localized, local intervention indicated »
Localized, local intervention indicated »
Symptomatic and medical intervention or minor cauterization indicated »
Localized, local intervention indicated »
Localized, local intervention indicated »
Localized, local intervention indicated »
Partial resection of injured organ/structure indicated »
Moderate pain; pain or analgesics interfering with function, but not interfering with ADL »
Change, adversely affecting patient or family »
Moderate petechiae; purpura »
Moderate pain; pain or analgesics interfering with function, but not interfering with ADL »
Symptomatic; altered GI function (e.g., altered dietary habits, diarrhea, or GI fluid loss); IV fluids indicated <24 hrs »
Symptomatic and medical intervention indicated »
Localized, local intervention indicated »
Localized, local intervention indicated »
Localized, local intervention indicated »
Partial resection of injured organ/structure indicated »
Symptomatic; medical intervention indicated »
Patchy ulcerations or pseudomembranes »
Upper aerodigestive tract sites: Symptomatic but can eat and swallow modified diet; respiratory symptoms interfering with function but not interfering with ADL… »
Symptomatic (e.g., noisy airway breathing), but causing no respiratory distress; medical management indicated (e.g., steroids) »
Symptomatic, tube thoracostomy or medical management indicated; associated with altered respiratory function but not interfering with ADL »
Symptomatic; altered GI function (e.g., altered dietary habits, vomiting, bleeding, diarrhea); IV fluids indicated <24 hrs »
Symptomatic; medical intervention indicated »
Symptomatic and interfering with function, but not interfering with ADL »
Symptomatic but not interfering with ADL; intervention not indicated »
Partial resection of injured organ/structure indicated »
<75,000 - 50,000/mm(3) <75.0 - 50.0 x 10e9 /L »
Symptomatic, tube thoracostomy or medical management indicated; associated with altered respiratory function but not interfering with ADL »
Symptomatic and medical intervention indicated »
Localized, local intervention indicated »
Localized, local intervention indicated »
Localized, local intervention indicated »
Partial resection of injured organ/structure indicated »
Moderate pain; pain or analgesics interfering with function, but not interfering with ADL »
Symptomatic, not interfering with ADL »
Symptomatic; intervention indicated (e.g., hospitalization for observation, tube placement without sclerosis) »
Decreased portal vein flow »
Partial resection of injured organ/structure indicated »
Physical signs of puberty <7 years for females, <9 years for males »
Symptoms not interfering with ADL; medical intervention indicated »
Extraordinary local care or maintenance; minor revision indicated »
Sclerosis or additional tube thoracostomy indicated »
Extubated within 24 - 72 hrs postoperatively »
QTc >0.47 - 0.50 second; >=0.06 second above baseline »
Symptomatic and interfering with function, but not interfering with ADL »
Gross bleeding, medical intervention, or urinary tract irrigation indicated »
Localized, local intervention indicated »
Localized, local intervention indicated »
Localized, local intervention indicated »
Partial resection of injured organ/structure indicated »
Symptomatic but no hydronephrosis, sepsis or renal dysfunction; dilation or endoscopic repair or stent placement indicated »
Moderate pain; pain or analgesics interfering with function, but not interfering with ADL »
Symptomatic, associated with altered renal/GU function »
Symptomatic but no hydronephrosis, sepsis or renal dysfunction; dilation or endoscopic repair or stent placement indicated »
2+ to 3+ or >1.0 - 3.5 g/24 hrs »
Intense or widespread »
Partial resection of injured organ/structure indicated »
Patchy or bi-basilar changes with estimated radiographic proportion of total lung volume that is fibrotic of 25 - <50% »
Asymptomatic, therapy indicated »
Partial resection of injured organ/structure indicated »
Non-urgent medical intervention indicated »
Symptomatic; interfering with function but not interfering with ADL »
Moderate to brisk erythema; patchy moist desquamation, mostly confined to skin folds and creases; moderate edema »
Macular or papular eruption or erythema with pruritus or other associated symptoms; localized desquamation or other lesions covering <50% of body surface… »
Scattered, but not generalized eruption »
Skin changes (e.g., peeling, blisters, bleeding, edema) or pain, not interfering with function »
Symptomatic and medical intervention or minor cauterization indicated »
Symptomatic; altered GI function (e.g., altered dietary habits, diarrhea, or GI fluid loss); IV fluids indicated <24 hrs »
Symptomatic and medical intervention or minor cauterization indicated »
Localized, local intervention indicated »
Localized, local intervention indicated »
Localized, local intervention indicated »
Partial resection of injured organ/structure indicated »
Symptomatic; medical intervention indicated »
Patchy ulcerations or pseudomembranes »
Upper aerodigestive tract sites: Symptomatic but can eat and swallow modified diet; respiratory symptoms interfering with function but not interfering with ADL… »
Symptomatic; altered GI function (e.g., altered dietary habits, vomiting, diarrhea, or GI fluid loss); IV fluids indicated <24 hrs »
Moderate pain; pain or analgesics interfering with function, but not interfering with ADL »
Medical intervention indicated; IV fluids indicated <24 hrs »
Symptomatic; altered GI function (e.g., altered dietary habits, vomiting, bleeding, diarrhea); IV fluids indicated <24 hrs »
Symptomatic; altered GI function (e.g., altered dietary habits, oral supplements); IV fluids indicated <24 hrs »
Partial resection of injured organ/structure indicated »
30 - 49% reduction in growth from the baseline growth curve »
Symptomatic and medical intervention indicated »
Asymptomatic, therapy indicated »
Partial resection of injured organ/structure indicated »
Exudative and visual acuity 20/40 or better but intervention not indicated »
Mild to moderate signs/symptoms; steroids indicated »
Symptomatic with moderate decrease in visual acuity (20/40 or better) »
Gross bleeding, medical intervention, or urinary tract irrigation indicated »
Asymptomatic, therapy indicated »
Symptomatic and interfering with function, but not interfering with ADL »
Moderate, narcotics indicated »
Partial resection of injured organ/structure indicated »
Partial resection of injured organ/structure indicated »
Symptomatic; altered GI function (e.g., altered dietary habits, diarrhea, or GI fluid loss); IV fluids indicated <24 hrs »
Localized, local intervention indicated »
Localized, local intervention indicated »
Localized, local intervention indicated »
Partial resection of injured organ/structure indicated »
Thick, ropy, sticky saliva; markedly altered taste; alteration in diet indicated; secretion-induced symptoms not interfering with ADL »
Moderate pain; pain or analgesics interfering with function, but not interfering with ADL »
Partial resection of injured organ/structure indicated »
Symptomatic, interfering with function but not interfering with ADL; moderate decrease in visual acuity (20/40 or better); medical intervention indicated »
Localized, local intervention indicated »
Localized, local intervention indicated »
Localized, local intervention indicated »
Partial resection of injured organ/structure indicated »
Moderate pain; pain or analgesics interfering with function, but not interfering with ADL »
One brief generalized seizure; seizure(s) well controlled by anticonvulsants or infrequent focal motor seizures not interfering with ADL »
Sensory alteration or paresthesia (including tingling), interfering with function, but not interfering with ADL »
Symptomatic; medical intervention or simple aspiration indicated »
2.5 - 5.0 x ULN »
2.5 - 5.0 x ULN »
11.5 - 12.5 mg/dL >2.9 - 3.1 mmol/L Ionized calcium >1.5 - 1.6 mmol/L »
300 - 400 mg/dL >7.75 - 10.34 mmol/L »
160 - 250 mg/dL >8.9 - 13.9 mmol/L »
5.5 - 6.0 mmol/L »
150 - 155 mmol/L »
2.5 - 5.0 x ULN »
<3 - 2 g/dL <30 - 20 g/L »
<8.0 - 7.0 mg/dL <2.0 - 1.75 mmol/L Ionized calcium <1.0 - 0.9 mmol/L »
<55 - 40 mg/dL <3.0 - 2.2 mmol/L »
<1.2 - 0.9 mg/dL <0.5 - 0.4 mmol/L »
<2.5 - 2.0 mg/dL <0.8 - 0.6 mmol/L »
Non-urgent medical intervention indicated »
Non-urgent medical intervention indicated »
Non-urgent medical intervention indicated »
Localized, local intervention indicated »
Localized, local intervention indicated »
Localized, local intervention indicated »
Partial resection of injured organ/structure indicated »
Moderate pain; pain or analgesics interfering with function, but not interfering with ADL »
Non-urgent medical intervention indicated »
Local wound care; medical intervention indicated »
Localized, local intervention indicated »
Localized, local intervention indicated »
Localized, local intervention indicated »
Partial resection of injured organ/structure indicated »
Moderate pain; pain or analgesics interfering with function, but not interfering with ADL »
Moderate valgus/varus deformity, symptomatic, interfering with function but not interfering with ADL »
Symptomatic; altered GI function (e.g., altered dietary habits, diarrhea, or GI fluid loss); IV fluids indicated <24 hrs »
Localized, local intervention indicated »
Localized, local intervention indicated »
Localized, local intervention indicated »
Symptomatic; medical intervention indicated »
Patchy ulcerations or pseudomembranes »
Upper aerodigestive tract sites: Symptomatic but can eat and swallow modified diet; respiratory symptoms interfering with function but not interfering with ADL… »
Partial resection of injured organ/structure indicated »
Symptomatic; altered GI function (e.g., altered dietary habits, vomiting, diarrhea, or GI fluid loss); IV fluids indicated <24 hrs »
Medical intervention indicated; IV fluids indicated <24 hrs »
Symptomatic; altered GI function (e.g., altered dietary habits, vomiting, bleeding, diarrhea); IV fluids indicated <24 hrs »
Symptomatic; altered GI function (e.g., altered dietary habits, oral supplements); IV fluids indicated <24 hrs »
Localized, local intervention indicated »
Localized, local intervention indicated »
Localized, local intervention indicated »
Partial resection of injured organ/structure indicated »
Somnolence or sedation interfering with function, but not interfering with ADL »
Awareness of receptive or expressive dysphasia, not impairing ability to communicate »
Gross bleeding, medical intervention, or urinary tract irrigation indicated »
Symptomatic; medical intervention indicated »
Symptomatic but no hydronephrosis, sepsis or renal dysfunction; dilation or endoscopic repair or stent placement indicated »
Symptomatic, associated with altered renal/GU function »
Symptomatic but no hydronephrosis, sepsis or renal dysfunction; dilation or endoscopic repair or stent placement indicated »
Localized, local intervention indicated »
Localized, local intervention indicated »
Localized, local intervention indicated »
Partial resection of injured organ/structure indicated »
Moderate accentuation; interfering with function but not interfering with ADL »
20 - 45 degrees; visible by forward flexion; interfering with function but not interfering with ADL »
Localized, local intervention indicated »
Localized, local intervention indicated »
Localized, local intervention indicated »
Partial resection of injured organ/structure indicated »
Prophylactic antibiotics indicated »
Non-urgent medical intervention indicated »
Symptomatic; altered GI function (e.g., altered dietary habits, vomiting, diarrhea, or GI fluid loss); IV fluids indicated <24 hrs »
Symptomatic; altered GI function (e.g., altered dietary habits, vomiting, bleeding, diarrhea); IV fluids indicated <24 hrs »
Symptomatic, associated with altered renal/GU function »
Symptomatic and medical intervention indicated »
Symptomatic; altered GI function (e.g., altered dietary habits, oral supplements); IV fluids indicated <24 hrs »
Symptomatic; altered GI function (e.g., altered dietary habits, diarrhea, or GI fluid loss); IV fluids indicated <24 hrs »
Symptomatic and medical intervention or minor cauterization indicated »
Localized, local intervention indicated »
Localized, local intervention indicated »
Localized, local intervention indicated »
Partial resection of injured organ/structure indicated »
Symptomatic; medical intervention indicated »
Patchy ulcerations or pseudomembranes »
Upper aerodigestive tract sites: Symptomatic but can eat and swallow modified diet; respiratory symptoms interfering with function but not interfering with ADL… »
Symptomatic; altered GI function (e.g., altered dietary habits, vomiting, diarrhea, or GI fluid loss); IV fluids indicated <24 hrs »
Moderate pain; pain or analgesics interfering with function, but not interfering with ADL »
Medical intervention indicated; IV fluids indicated <24 hrs »
Symptomatic; altered GI function (e.g., altered dietary habits, vomiting, bleeding, diarrhea); IV fluids indicated <24 hrs »
Symptomatic; altered GI function (e.g., altered dietary habits, oral supplements); IV fluids indicated <24 hrs »
Partial resection of injured organ/structure indicated »
Symptomatic (e.g., claudication); not interfering with ADL; repair or revision not indicated »
Non-urgent medical intervention indicated »
Non-urgent medical intervention indicated »
Non-urgent medical intervention indicated »
Altered taste with change in diet (e.g., oral supplements); noxious or unpleasant taste; loss of taste »
Partial resection of injured organ/structure indicated »
Partial resection of injured organ/structure indicated »
Gross bleeding, medical intervention, or urinary tract irrigation indicated »
Symptomatic but no hydronephrosis, sepsis or renal dysfunction; dilation or endoscopic repair or stent placement indicated »
Symptomatic, associated with altered renal/GU function »
Symptomatic but no hydronephrosis, sepsis or renal dysfunction; dilation or endoscopic repair or stent placement indicated »
Moderate pain; pain or analgesics interfering with function, but not interfering with ADL »
Partial resection of injured organ/structure indicated »
Partial resection of injured organ/structure indicated »
Partial resection of injured organ/structure indicated »
Local wound care; medical intervention indicated »
Moderate pain; pain or analgesics interfering with function, but not interfering with ADL »
Deep vein thrombosis or cardiac thrombosis; intervention (e.g., anticoagulation, lysis, filter, invasive procedure) not indicated »
Deep vein thrombosis or cardiac thrombosis; intervention (e.g., anticoagulation, lysis, filter, invasive procedure) not indicated »
Symptomatic, not interfering with ADL; thyroid suppression therapy indicated »
Symptomatic, not interfering with ADL; thyroid replacement indicated »
Partial resection of injured organ/structure indicated »
Tinnitus not interfering with ADL »
Partial resection of injured organ/structure indicated »
Functional impairment correctable with oral surgery »
Non-urgent medical intervention indicated »
Symptomatic, tube thoracostomy or medical management indicated; associated with altered respiratory function but not interfering with ADL »
Symptomatic and medical intervention indicated »
Localized, local intervention indicated »
Localized, local intervention indicated »
Localized, local intervention indicated »
Partial resection of injured organ/structure indicated »
Patchy ulcerations or pseudomembranes »
Upper aerodigestive tract sites: Symptomatic but can eat and swallow modified diet; respiratory symptoms interfering with function but not interfering with ADL… »
Symptomatic (e.g., noisy airway breathing), but causing no respiratory distress; medical management indicated (e.g., steroids) »
Moderate tremor interfering with function, but not interfering with ADL »
Non-urgent medical intervention indicated »
Decreased range of motion requiring small bites, soft foods or purees »
Symptomatic and interfering with function, but not interfering with ADL »
Moderate pain; pain or analgesics interfering with function, but not interfering with ADL »
Moderate pain; pain or analgesics interfering with function, but not interfering with ADL »
Abdominal pain; mucus or blood in stool »
Superficial ulceration <2 cm size; local wound care; medical intervention indicated »
Localized, local intervention indicated »
Localized, local intervention indicated »
Localized, local intervention indicated »
Localized, local intervention indicated »
Localized, local intervention indicated »
Localized, local intervention indicated »
Partial resection of injured organ/structure indicated »
Localized, local intervention indicated »
Localized, local intervention indicated »
Localized, local intervention indicated »
Partial resection of injured organ/structure indicated »
Symptomatic (e.g., claudication); not interfering with ADL; repair or revision not indicated »
Partial resection of injured organ/structure indicated »
Able to perform most household or work activities with compensation from unaffected limb »
Partial resection of injured organ/structure indicated »
Symptomatic and interfering with function, but not interfering with ADL »
Local wound care; medical intervention indicated »
Symptomatic (e.g., claudication); not interfering with ADL; repair or revision not indicated »
Partial resection of injured organ/structure indicated »
Symptomatic and medical intervention or minor cauterization indicated »
Symptomatic; noninvasive intervention indicated »
Gross bleeding, medical intervention, or urinary tract irrigation indicated »
Localized, local intervention indicated »
Localized, local intervention indicated »
Localized, local intervention indicated »
Partial resection of injured organ/structure indicated »
Symptomatic; medical intervention indicated »
Symptomatic but no hydronephrosis, sepsis or renal dysfunction; dilation or endoscopic repair or stent placement indicated »
Symptomatic, associated with altered renal/GU function »
Symptomatic but no hydronephrosis, sepsis or renal dysfunction; dilation or endoscopic repair or stent placement indicated »
Symptomatic; noninvasive intervention indicated »
Gross bleeding, medical intervention, or urinary tract irrigation indicated »
Localized, local intervention indicated »
Localized, local intervention indicated »
Localized, local intervention indicated »
Partial resection of injured organ/structure indicated »
Symptomatic; medical intervention indicated »
Symptomatic but no hydronephrosis, sepsis or renal dysfunction; dilation or endoscopic repair or stent placement indicated »
Moderate pain; pain or analgesics interfering with function, but not interfering with ADL »
Symptomatic, associated with altered renal/GU function »
Symptomatic but no hydronephrosis, sepsis or renal dysfunction; dilation or endoscopic repair or stent placement indicated »
Partial resection of injured organ/structure indicated »
Mild, reversible and manageable with replacement »
Increase >2 x normal but <hourly »
Gross bleeding, medical intervention, or urinary tract irrigation indicated »
Spontaneous, pads indicated »
Hesitancy requiring medication; or operative bladder atony requiring indwelling catheter beyond immediate postoperative period but for <6 weeks »
Localized, local intervention indicated »
Localized, local intervention indicated »
Localized, local intervention indicated »
Partial resection of injured organ/structure indicated »
Intervention indicated for <24 hrs »
Symptomatic; noninvasive intervention indicated »
Gross bleeding, medical intervention, or urinary tract irrigation indicated »
Localized, local intervention indicated »
Localized, local intervention indicated »
Localized, local intervention indicated »
Partial resection of injured organ/structure indicated »
Symptomatic; medical intervention indicated »
Symptomatic but no hydronephrosis, sepsis or renal dysfunction; dilation or endoscopic repair or stent placement indicated »
Moderate pain; pain or analgesics interfering with function, but not interfering with ADL »
Symptomatic, associated with altered renal/GU function »
Symptomatic but no hydronephrosis, sepsis or renal dysfunction; dilation or endoscopic repair or stent placement indicated »
Anterior uveitis; medical intervention indicated »
Symptomatic; noninvasive intervention indicated »
Gross bleeding, medical intervention, or urinary tract irrigation indicated »
Localized, local intervention indicated »
Localized, local intervention indicated »
Localized, local intervention indicated »
Partial resection of injured organ/structure indicated »
Symptomatic; medical intervention indicated »
Symptomatic but no hydronephrosis, sepsis or renal dysfunction; dilation or endoscopic repair or stent placement indicated »
Moderate pain; pain or analgesics interfering with function, but not interfering with ADL »
Symptomatic, associated with altered renal/GU function »
Symptomatic but no hydronephrosis, sepsis or renal dysfunction; dilation or endoscopic repair or stent placement indicated »
Interfering with sexual function; dyspareunia; intervention indicated »
Patchy ulcerations; moderate symptoms or dyspareunia »
Vaginal narrowing and/or shortening interfering with function »
Moderate, intervention indicated »
Asymptomatic; moderate regurgitation or stenosis by imaging »
Gross bleeding, medical intervention, or urinary tract irrigation indicated »
Symptomatic; medical intervention indicated »
Symptomatic but no hydronephrosis, sepsis or renal dysfunction; dilation or endoscopic repair or stent placement indicated »
Symptomatic, associated with altered renal/GU function »
Symptomatic but no hydronephrosis, sepsis or renal dysfunction; dilation or endoscopic repair or stent placement indicated »
Symptomatic, non-steroidal medical intervention indicated »
Present without loss of consciousness »
Localized, local intervention indicated »
Localized, local intervention indicated »
Localized, local intervention indicated »
Partial resection of injured organ/structure indicated »
Non-urgent medical intervention indicated »
Non-urgent medical intervention indicated »
Non-urgent medical intervention indicated »
Non-urgent medical intervention indicated »
Transaminases abnormal, liver function normal »
Symptomatic (e.g., claudication); not interfering with ADL; repair or revision not indicated »
Symptomatic (e.g., claudication); not interfering with ADL; repair or revision not indicated »
<75 - 50% of predicted value »
Symptomatic, interfering with function, but not interfering with ADL; intervention not indicated »
Moderate or persistent voice changes, may require occasional repetition but understandable on telephone »
2 - 5 episodes in 24 hrs; IV fluids indicated <24 hrs »
Localized, local intervention indicated »
Localized, local intervention indicated »
Localized, local intervention indicated »
Partial resection of injured organ/structure indicated »
10 - <20% of baseline »
10 - <20% from baseline; nutritional support indicated »
Symptomatic and interfering with function, but not interfering with ADL »
Non-urgent medical intervention indicated »
Localized, local intervention indicated »
Localized, local intervention indicated »
Localized, local intervention indicated »
Symptomatic (dry or thick saliva) without significant dietary alteration; unstimulated saliva flow >0.2 ml/min »
Symptomatic and severely altered GI function (e.g., altered dietary habits, diarrhea, or GI fluid loss); IV fluids, tube feedings, or TPN indicated… »
Transfusion, interventional radiology, endoscopic, or operative intervention indicated; radiation therapy (i.e., hemostasis of bleeding site) »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
Complete resection or reconstruction of injured organ/structure indicated »
Severe pain; pain or analgesics severely interfering with ADL »
Operative debridement or other invasive intervention indicated (e.g., hyperbaric oxygen) »
Symptomatic, interfering with GI function »
Respiratory compromise or fluids indicated »
Complete resection or reconstruction of injured organ/structure indicated »
Present, intubation not indicated »
Severe mood alteration interfering with ADL »
5.0 - 20.0 x ULN »
Symptomatic bronchospasm, with or without urticaria; parenteral medication(s) indicated; allergy-related edema/angioedema; hypotension »
2.0 - 5.0 x ULN »
Interfering with ADL; operative intervention indicated »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
Complete resection or reconstruction of injured organ/structure indicated »
Associated with significant weight loss or malnutrition (e.g., inadequate oral caloric and/or fluid intake); IV fluids, tube feedings or TPN indicated … »
Symptomatic and severely altered GI function (e.g., altered dietary habits, diarrhea, or GI fluid loss); IV fluids, tube feedings, or TPN indicated… »
Transfusion, interventional radiology, endoscopic, or operative intervention indicated; radiation therapy (i.e., hemostasis of bleeding site) »
Complete resection or reconstruction of injured organ/structure indicated »
Erythema of the mucosa »
Upper aerodigestive tract sites: Symptomatic and unable to adequately aliment or hydrate orally; respiratory symptoms interfering with ADL Lower GI sites: Stool… »
Inability to aliment adequately by GI tract (e.g., requiring enteral or parenteral nutrition); interventional radiology, endoscopic, or operative intervention indicated »
Severe pain; pain or analgesics severely interfering with ADL »
Symptomatic and severely altered GI function (e.g., altered dietary habits, diarrhea, or GI fluid loss); IV fluids, tube feedings, or TPN indicated… »
Symptomatic and severely altered GI function (e.g., inadequate oral caloric or fluid intake); IV fluids, tube feedings, or TPN indicated >=24 hrs… »
Severe mood alteration interfering with ADL »
Symptomatic interfering with ADL; repair or revision indicated »
Complete resection or reconstruction of injured organ/structure indicated »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
Complete resection or reconstruction of injured organ/structure indicated »
IV fluids, tube feedings, or TPN indicated >=24 hrs; operative intervention indicated »
Symptomatic, interfering with ADL »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
Complete resection or reconstruction of injured organ/structure indicated »
Clinical or radiographic signs of pneumonia or pneumonitis; unable to aliment orally »
Unable to use dentures or prosthesis at any time »
Full mouth extractions indicated »
Incompletely controlled medically or controlled with device (e.g., pacemaker) »
Symptomatic, interfering with ADL; mechanical assistance indicated »
Operative (e.g., stent, laser) intervention indicated »
Symptomatic and incompletely controlled medically, or controlled with device (e.g., pacemaker) »
Symptomatic and incompletely controlled medically, or controlled with device (e.g., pacemaker) »
Symptomatic and incompletely controlled medically, or controlled with device (e.g., pacemaker) »
Reversible autoimmune reaction involving function of a major organ or other adverse event (e.g., transient colitis or anemia) »
Incompletely controlled medically or controlled with device (e.g., pacemaker) »
Incompletely controlled medically or controlled with device (e.g., pacemaker) »
Incompletely controlled medically or controlled with device (e.g., pacemaker) »
Incompletely controlled medically or controlled with device (e.g., pacemaker) »
Symptomatic and interfering with ADL; operative intervention or hyperbaric oxygen indicated »
Severe pain; pain or analgesics severely interfering with ADL »
Symptomatic and incompletely controlled medically or controlled with device (e.g., defibrillator) »
Complete resection or reconstruction of injured organ/structure indicated »
Complete resection or reconstruction of injured organ/structure indicated »
Symptomatic and severely altered GI function (e.g., altered dietary habits, diarrhea, or GI fluid loss); IV fluids, tube feedings, or TPN indicated… »
Transfusion, interventional radiology, endoscopic, or operative intervention indicated; radiation therapy (i.e., hemostasis of bleeding site) »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
Symptomatic and interfering with GI function; invasive or endoscopic intervention indicated »
Complete resection or reconstruction of injured organ/structure indicated »
Complete resection or reconstruction of injured organ/structure indicated »
IV fluids, tube feedings, or TPN indicated >=24 hrs; operative intervention indicated »
Complete resection or reconstruction of injured organ/structure indicated »
Symptomatic and severely altered GI function (e.g., altered dietary habits, diarrhea, or GI fluid loss); IV fluids, tube feedings, or TPN indicated… »
Symptomatic interfering with ADL; invasive intervention indicated »
Transfusion, interventional radiology, endoscopic, or operative intervention indicated; radiation therapy (i.e., hemostasis of bleeding site) »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
Complete resection or reconstruction of injured organ/structure indicated »
Symptomatic, interfering with GU function; invasive or endoscopic intervention indicated »
Symptomatic and altered organ function (e.g., sepsis or hydronephrosis, or renal dysfunction); operative intervention indicated »
Severe pain; pain or analgesics severely interfering with ADL »
Symptomatic, operative intervention indicated »
Symptomatic and altered organ function (e.g., sepsis or hydronephrosis, or renal dysfunction); operative intervention indicated »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
Symptomatic and interfering with ADL »
Severe length discrepancy >5 cm; operative intervention indicated; interfering with ADL »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
Complete resection or reconstruction of injured organ/structure indicated »
Severely hypocellular or >50 - <=75% reduction cellularity from normal for age »
Severe pain; pain or analgesics severely interfering with ADL »
Symptomatic, interfering with ADL »
Complete resection or reconstruction of injured organ/structure indicated »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
Complete resection or reconstruction of injured organ/structure indicated »
Complete resection or reconstruction of injured organ/structure indicated »
Marked deviation of nipple projection »
Severe pain; pain or analgesics severely interfering with ADL »
Asymmetry exists, >1/3 of the breast volume; severe hypoplasia »
Transfusion, interventional radiology, endoscopic, or operative intervention indicated; radiation therapy (i.e., hemostasis of bleeding site) »
Symptomatic interfering with function »
Symptomatic and associated with altered respiratory function interfering with ADL; or endoscopic (e.g., stent) or primary closure by operative intervention indicated … »
Transfusion, interventional radiology, endoscopic, or operative intervention indicated; radiation therapy (i.e., hemostasis of bleeding site) »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
Complete resection or reconstruction of injured organ/structure indicated »
Interfering with ADL; stridor or endoscopic intervention indicated (e.g., stent, laser) »
Moderate to major debridement or reconstruction indicated »
Severe pain; pain or analgesics severely interfering with ADL »
<50 - 25% of predicted value »
Severe pain; pain or analgesics severely interfering with ADL »
Symptomatic and testing consistent with ischemia; unstable angina; intervention indicated »
Levels consistent with unstable angina as defined by the manufacturer »
0.1 - <0.2 ng/mL »
Symptomatic interfering with ADL; repair or revision indicated »
Complete resection or reconstruction of injured organ/structure indicated »
Complete resection or reconstruction of injured organ/structure indicated »
Symptomatic with marked decrease in visual acuity (worse than 20/40); operative intervention indicated (e.g., cataract surgery) »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
<200 - 50/mm(3) <0.2 x 0.05 - 10e9 /L »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
Complete resection or reconstruction of injured organ/structure indicated »
Symptomatic and severely altered GI function (e.g., altered dietary habits, vomiting, diarrhea, or GI fluid loss); IV fluids, tube feedings, or TPN… »
Transfusion, interventional radiology, endoscopic, or operative intervention indicated; radiation therapy (i.e., hemostasis of bleeding site) »
IV fluids, tube feedings, or TPN indicated >=24 hrs; operative intervention indicated »
Symptomatic and severely altered GI function (e.g., altered dietary habits, diarrhea, or GI fluid loss); IV fluids, tube feedings, or TPN indicated… »
Symptomatic and severely altered GI function (e.g., inadequate oral caloric or fluid intake); IV fluids, tube feedings, or TPN indicated >=24 hrs… »
Ventriculostomy, ICP monitoring, intraventricular thrombolysis, or operative intervention indicated »
Complete resection or reconstruction of injured organ/structure indicated »
Symptomatic, interfering with ADL; operative intervention indicated »
Ankylosed/fused over multiple segments with no C-spine rotation »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
Complete resection or reconstruction of injured organ/structure indicated »
Symptomatic, interfering with ADL »
Moist desquamation other than skin folds and creases; bleeding induced by minor trauma or abrasion »
Severe pain; pain or analgesics severely interfering with ADL »
Severe pain; pain or analgesics severely interfering with ADL »
Interventional radiology, endoscopic, or operative intervention indicated »
Interventional radiology or operative intervention indicated »
Operative intervention indicated »
Symptomatic, interfering with ADL »
Symptomatic, interfering with ADL »
Symptomatic, interfering with ADL »
Abdominal pain, fever, change in bowel habits with ileus; peritoneal signs »
Transfusion, interventional radiology, endoscopic, or operative intervention indicated; radiation therapy (i.e., hemostasis of bleeding site) »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
Complete resection or reconstruction of injured organ/structure indicated »
Symptomatic and severely altered GI function (e.g., altered dietary habits, vomiting, diarrhea, or GI fluid loss); IV fluids, tube feedings, or TPN… »
Symptomatic and severely altered GI function (e.g., altered dietary habits, diarrhea, or GI fluid loss); IV fluids, tube feedings, or TPN indicated… »
Inability to aliment adequately by GI tract (e.g., requiring enteral or parenteral nutrition); interventional radiology, endoscopic, or operative intervention indicated »
IV fluids, tube feedings, or TPN indicated >=24 hrs; operative intervention indicated »
Symptomatic and severely altered GI function (e.g., altered dietary habits, diarrhea, or GI fluid loss); IV fluids, tube feedings, or TPN indicated… »
Symptomatic and severely altered GI function (e.g., inadequate oral caloric or fluid intake); IV fluids, tube feedings, or TPN indicated >=24 hrs… »
Incompletely controlled medically or controlled with device (e.g., pacemaker) »
Symptomatic, interfering with ADL »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
Complete resection or reconstruction of injured organ/structure indicated »
Symptoms interfering with ADL; obstipation with manual evacuation indicated »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
Complete resection or reconstruction of injured organ/structure indicated »
Symptomatic and significantly interfering with sleep or ADL »
Complete resection or reconstruction of injured organ/structure indicated »
Transient ischemic event or attack (TIA) <=24 hrs duration »
Complete resection or reconstruction of injured organ/structure indicated »
Symptomatic and interfering with ADL; hyperbaric oxygen indicated »
Complete resection or reconstruction of injured organ/structure indicated »
Severe cognitive disability; significant impairment of work/school/life performance »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
Complete resection or reconstruction of injured organ/structure indicated »
Confusion or delirium interfering with ADL »
Complete resection or reconstruction of injured organ/structure indicated »
Symptomatic, interfering with ADL »
Complete resection or reconstruction of injured organ/structure indicated »
Complete resection or reconstruction of injured organ/structure indicated »
Complete resection or reconstruction of injured organ/structure indicated »
Symptomatic, interfering with ADL »
Complete resection or reconstruction of injured organ/structure indicated »
Complete resection or reconstruction of injured organ/structure indicated »
Symptomatic, interfering with ADL »
Complete resection or reconstruction of injured organ/structure indicated »
Symptomatic, interfering with ADL »
Complete resection or reconstruction of injured organ/structure indicated »
Complete resection or reconstruction of injured organ/structure indicated »
Symptomatic, interfering with ADL »
Complete resection or reconstruction of injured organ/structure indicated »
Symptomatic, interfering with ADL »
Complete resection or reconstruction of injured organ/structure indicated »
Symptomatic, interfering with ADL »
Complete resection or reconstruction of injured organ/structure indicated »
Symptomatic, interfering with ADL »
5 x ULN - 10 x ULN »
3.0 - 6.0 x ULN »
Transfusion; IV pain medications; bladder irrigation indicated »
Prolonged (i.e., not rapidly responsive to symptomatic medication and/or brief interruption of infusion); recurrence of symptoms following initial improvement; hospitalization indicated for… »
IV fluids indicated >=24 hrs »
No sexual development by age 14 yrs for girls, age 16 yrs for boys; hormone replacement indicated »
Severe pain; pain or analgesics severely interfering with ADL »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
Severe mood alteration interfering with ADL »
Increase of >=7 stools per day over baseline; incontinence; IV fluids >=24 hrs; hospitalization; severe increase in ostomy output compared to baseline;… »
Laboratory findings and bleeding »
Interfering with ADL »
Symptomatic or decrease in visual acuity interfering with ADL; operative intervention indicated »
Interfering with ADL »
Symptomatic and severely altered GI function (e.g., altered dietary habits, diarrhea, or GI fluid loss); IV fluids, tube feedings, or TPN indicated… »
Transfusion, interventional radiology, endoscopic, or operative intervention indicated; radiation therapy (i.e., hemostasis of bleeding site) »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
Complete resection or reconstruction of injured organ/structure indicated »
Inability to aliment adequately by GI tract (e.g., requiring enteral or parenteral nutrition); interventional radiology, endoscopic, or operative intervention indicated »
Symptomatic and severely altered GI function (e.g., altered dietary habits, vomiting, diarrhea, or GI fluid loss); IV fluids, tube feedings, or TPN… »
IV fluids, tube feedings, or TPN indicated >=24 hrs; operative intervention indicated »
Symptomatic and severely altered GI function (e.g., altered dietary habits, diarrhea, or GI fluid loss); IV fluids, tube feedings, or TPN indicated… »
Symptomatic and severely altered GI function (e.g., inadequate oral caloric or fluid intake); IV fluids, tube feedings, or TPN indicated >=24 hrs… »
Symptomatic and severely altered eating/swallowing (e.g., inadequate oral caloric or fluid intake); IV fluids, tube feedings, or TPN indicated >=24 hrs … »
Dyspnea with ADL »
Generalized facial or neck edema with functional impairment (e.g., difficulty in turning neck or opening mouth compared to baseline) »
30% inter-limb discrepancy in volume; lymphorrhea; gross deviation from normal anatomic contour; interfering with ADL »
Lymphorrhea; interfering with ADL; gross deviation from normal anatomic contour »
Symptomatic and unable to aliment adequately orally; interventional radiology or operative intervention indicated »
Signs or symptoms interfering with ADL; hospitalization indicated »
Abdominal pain, fever, change in bowel habits with ileus; peritoneal signs »
Symptomatic, interfering with ADL »
Decrease in erectile function (frequency/rigidity of erections) but erectile aids not helpful; penile prosthesis indicated »
Transfusion, interventional radiology, endoscopic, or operative intervention indicated; radiation therapy (i.e., hemostasis of bleeding site) »
Symptomatic and severely altered eating/swallowing (e.g., inadequate oral caloric or fluid intake); IV fluids, tube feedings, or TPN indicated >=24 hrs … »
Symptomatic and severely altered GI function (e.g., altered dietary habits, diarrhea, or GI fluid loss); IV fluids, tube feedings, or TPN indicated… »
Transfusion, interventional radiology, endoscopic, or operative intervention indicated; radiation therapy (i.e., hemostasis of bleeding site) »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
Complete resection or reconstruction of injured organ/structure indicated »
Symptomatic and interfering with GI function; invasive or endoscopic intervention indicated »
Erythema of the mucosa »
Upper aerodigestive tract sites: Symptomatic and unable to adequately aliment or hydrate orally; respiratory symptoms interfering with ADL Lower GI sites: Stool… »
Inability to aliment adequately by GI tract (e.g., requiring enteral or parenteral nutrition); interventional radiology, endoscopic, or operative intervention indicated »
Symptomatic and severely altered GI function (e.g., altered dietary habits, vomiting, diarrhea, or GI fluid loss); IV fluids, tube feedings, or TPN… »
Severe pain; pain or analgesics severely interfering with ADL »
IV fluids, tube feedings, or TPN indicated >=24 hrs; operative intervention indicated »
Symptomatic and severely altered GI function (e.g., altered dietary habits, diarrhea, or GI fluid loss); IV fluids, tube feedings, or TPN indicated… »
Symptomatic and severely altered GI function (e.g., inadequate oral caloric or fluid intake); IV fluids, tube feedings, or TPN indicated >=24 hrs… »
Severe mood alteration interfering with ADL »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
Severe pain; pain or analgesics severely interfering with ADL »
Symptomatic and interfering with ADL »
Severe involuntary movements or torticollis interfering with ADL »
Severe pain; pain or analgesics severely interfering with ADL »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
Complete resection or reconstruction of injured organ/structure indicated »
Severe pain; pain or analgesics severely interfering with ADL »
Symptomatic; interfering with ADL; surgical intervention indicated »
Complete resection or reconstruction of injured organ/structure indicated »
Severe pain; pain or analgesics severely interfering with ADL »
Symptomatic and interfering with ADL »
Transfusion, interventional radiology, endoscopic, or operative intervention indicated; radiation therapy (i.e., hemostasis of bleeding site) »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
Complete resection or reconstruction of injured organ/structure indicated »
Symptomatic, interfering with GU function; invasive or endoscopic intervention indicated »
Symptomatic and altered organ function (e.g., sepsis or hydronephrosis, or renal dysfunction); operative intervention indicated »
Symptomatic, operative intervention indicated »
Symptomatic and altered organ function (e.g., sepsis or hydronephrosis, or renal dysfunction); operative intervention indicated »
Severe fatigue interfering with ADL »
Symptomatic interfering with ADL; invasive intervention indicated »
<50 - 25% of predicted value »
40.0 degrees C (>104.0 degrees F) for <=24 hrs »
<0.5 - 0.25 x LLN or 50 - <75% decrease from baseline »
Significant disfigurement; operative intervention indicated if patient chooses »
Increased density with fixation of tissue; operative intervention indicated; interfering with ADL »
Symptomatic and interfering with ADL »
Severe symptoms interfering with ADL »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
Symptomatic and displaced or open wound with bone exposure; operative intervention indicated »
Symptomatic and severely altered GI function (e.g., altered dietary habits, diarrhea, or GI fluid loss); IV fluids, tube feedings, or TPN indicated… »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
Complete resection or reconstruction of injured organ/structure indicated »
Inability to aliment adequately by GI tract (e.g., requiring enteral or parenteral nutrition); interventional radiology, endoscopic, or operative intervention indicated »
Symptomatic and severely altered GI function (e.g., altered dietary habits, vomiting, diarrhea, or GI fluid loss); IV fluids, tube feedings, or TPN… »
Severe pain; pain or analgesics severely interfering with ADL »
IV fluids, tube feedings, or TPN indicated >=24 hrs; operative intervention indicated »
5.0 - 20.0 x ULN »
Symptomatic and severely altered gastric function (e.g., inadequate oral caloric or fluid intake); IV fluids, tube feedings, or TPN indicated >24 hrs… »
Symptomatic and interfering with GI function; invasive or endoscopic intervention indicated »
Transfusion, interventional radiology, endoscopic, or operative intervention indicated; radiation therapy (i.e., hemostasis of bleeding site) »
Complete resection or reconstruction of injured organ/structure indicated »
Symptomatic and interfering with GI function; invasive or endoscopic intervention indicated »
Transfusion, interventional radiology, endoscopic, or operative intervention indicated; radiation therapy (i.e., hemostasis of bleeding site) »
Symptomatic, interfering with GU function; invasive or endoscopic intervention indicated »
Symptomatic and altered organ function (e.g., sepsis or hydronephrosis, or renal dysfunction); operative intervention indicated »
Dysfunctional stoma; operative intervention or major stomal revision indicated »
Symptomatic and altered organ function (e.g., sepsis or hydronephrosis, or renal dysfunction); operative intervention indicated »
Complete resection or reconstruction of injured organ/structure indicated »
EIOP causing marked visual field deficits (i.e., involving both superior and inferior visual fields); operative intervention indicated »
<25% LLN, chronic dialysis not indicated »
Symptomatic breast enlargement; intervention indicated »
Severe pain; pain or analgesics severely interfering with ADL »
Operative debridement or other invasive intervention indicated (e.g., hyperbaric oxygen) »
Adult only: Threshold shift of >25 - 90 dB, averaged at 3 contiguous test frequencies in at least one ear Pediatric: Hearing… »
Hearing loss requiring hearing aid or intervention (i.e., interfering with ADL) »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
Complete resection or reconstruction of injured organ/structure indicated »
Transfusion, interventional radiology, or operative intervention indicated »
<8.0 - 6.5 g/dL <4.9 - 4.0 mmol/L <80 - 65 g/L »
Transfusion or medical intervention (e.g., steroids) indicated »
Requiring transfusion of 2 units non-autologous (10 cc/kg for pediatrics) pRBCs beyond protocol specification; postoperative interventional radiology, endoscopic, or operative intervention indicated… »
Interfering with ADL; interventional radiology, endoscopic, or operative intervention indicated »
Complete resection or reconstruction of injured organ/structure indicated »
Inability to aliment adequately by GI tract (e.g., requiring enteral or parenteral nutrition); interventional radiology, endoscopic, or operative intervention indicated »
Complete resection or reconstruction of injured organ/structure indicated »
Symptomatic, significantly interfering with sleep or ADL »
Interfering with ADL »
Severe symptoms or neurological deficit interfering with ADL »
3.0 - 10.0 x ULN »
Requiring more than one drug or more intensive therapy than previously Pediatric: Same as adult »
Sustained (>=24 hrs) therapy, resolves without persisting physiologic consequences »
32 - >28 degrees C 89.6 - >82.4 degrees F »
Decreased O(2) saturation at rest; continuous oxygen indicated »
Symptomatic and incompletely controlled medically or controlled with device (e.g., defibrillator) »
Symptomatic and severely altered GI function (e.g., altered dietary habits, diarrhea, or GI fluid loss); IV fluids, tube feedings, or TPN indicated… »
Transfusion, interventional radiology, endoscopic, or operative intervention indicated; radiation therapy (i.e., hemostasis of bleeding site) »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
Complete resection or reconstruction of injured organ/structure indicated »
Inability to aliment adequately by GI tract (e.g., requiring enteral or parenteral nutrition); interventional radiology, endoscopic, or operative intervention indicated »
Symptomatic and severely altered GI function (e.g., altered dietary habits, vomiting, diarrhea, or GI fluid loss); IV fluids, tube feedings, or TPN… »
IV fluids, tube feedings, or TPN indicated >=24 hrs; operative intervention indicated »
Symptomatic and severely altered GI function (e.g., altered dietary habits, diarrhea, or GI fluid loss); IV fluids, tube feedings, or TPN indicated… »
Symptomatic and severely altered GI function (e.g., inadequate oral caloric or fluid intake); IV fluids, tube feedings, or TPN indicated >=24 hrs… »
Symptomatic and severely altered GI function; IV fluids, tube feeding, or TPN indicated >24 hrs »
Dysfunction interfering with ADL; very marked density, retraction or fixation »
IV antibiotics or TPN indicated »
Complete resection or reconstruction of injured organ/structure indicated »
Symptomatic interfering with ADL; repair or revision indicated »
Male: sterile/azoospermia Female: infertile/anovulatory »
Ulceration or necrosis that is severe; operative intervention indicated »
Complete resection or reconstruction of injured organ/structure indicated »
Frequent difficulty sleeping, interfering with ADL »
Severe pain; pain or analgesics severely interfering with ADL »
Iron overload, intervention indicated »
Persistent amenorrhea for >6 months »
Symptomatic and severely altered GI function (e.g., altered dietary habits, diarrhea, or GI fluid loss); IV fluids, tube feedings, or TPN indicated… »
Transfusion, interventional radiology, endoscopic, or operative intervention indicated; radiation therapy (i.e., hemostasis of bleeding site) »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
Complete resection or reconstruction of injured organ/structure indicated »
Inability to aliment adequately by GI tract (e.g., requiring enteral or parenteral nutrition); interventional radiology, endoscopic, or operative intervention indicated »
Symptomatic and severely altered GI function (e.g., altered dietary habits, vomiting, diarrhea, or GI fluid loss); IV fluids, tube feedings, or TPN… »
IV fluids, tube feedings, or TPN indicated >=24 hrs; operative intervention indicated »
Symptomatic and severely altered GI function (e.g., altered dietary habits, diarrhea, or GI fluid loss); IV fluids, tube feedings, or TPN indicated… »
Symptomatic and severely altered GI function (e.g., inadequate oral caloric or fluid intake); IV fluids, tube feedings, or TPN indicated >=24 hrs… »
Symptomatic and interfering with ADL »
Stiffness interfering with ADL; >50 - 75% decrease in ROM »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
Complete resection or reconstruction of injured organ/structure indicated »
Severe pain; pain or analgesics severely interfering with ADL »
Symptomatic interfering with ADL; repair or revision indicated »
Complete resection or reconstruction of injured organ/structure indicated »
Symptomatic and interfering with ADL; operative intervention indicated »
Symptomatic interfering with ADL; invasive intervention indicated »
Transfusion, interventional radiology, endoscopic, or operative intervention indicated; radiation therapy (i.e., hemostasis of bleeding site) »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
Complete resection or reconstruction of injured organ/structure indicated »
Symptomatic, interfering with GU function; invasive or endoscopic intervention indicated »
Severe pain; pain or analgesics severely interfering with ADL »
Symptomatic, operative intervention indicated »
Symptomatic and interfering with GI function; invasive or endoscopic intervention indicated »
Confluent ulcerations or pseudomembranes; bleeding with minor trauma »
Upper aerodigestive tract sites: Symptomatic and unable to adequately aliment or hydrate orally; respiratory symptoms interfering with ADL Lower GI sites: Stool… »
Symptomatic, interfering with ADL; intervention indicated (e.g., thyroplasty, vocal cord injection) »
Stridor; respiratory distress; interfering with ADL »
Symptomatic and associated with altered respiratory function interfering with ADL; or endoscopic (e.g., stent) or primary closure by operative intervention indicated … »
Transfusion, interventional radiology, endoscopic, or operative intervention indicated; radiation therapy (i.e., hemostasis of bleeding site) »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
Complete resection or reconstruction of injured organ/structure indicated »
Confluent ulcerations or pseudomembranes; bleeding with minor trauma »
Upper aerodigestive tract sites: Symptomatic and unable to adequately aliment or hydrate orally; respiratory symptoms interfering with ADL Lower GI sites: Stool… »
Interfering with ADL; stridor or endoscopic intervention indicated (e.g., stent, laser) »
Severe pain; pain or analgesics severely interfering with ADL »
Symptomatic CHF responsive to intervention »
Symptomatic CHF responsive to intervention; EF <40 - 20% SF <15% »
Symptomatic and interfering with ADL »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
Complete resection or reconstruction of injured organ/structure indicated »
<2000 - 1000/mm(3) <2.0 - 1.0 x 10e9 /L »
Severe increase in SAS; severe ventriculomegaly; near total white matter T2 hyperintensities or diffuse low attenuation (CT) »
Complete resection or reconstruction of injured organ/structure indicated »
Complete resection or reconstruction of injured organ/structure indicated »
Complete resection or reconstruction of injured organ/structure indicated »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
Severe pain; pain or analgesics severely interfering with ADL »
2.0 - 5.0 x ULN »
Transfusion, interventional radiology, endoscopic, or operative intervention indicated; radiation therapy (i.e., hemostasis of bleeding site) »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
Complete resection or reconstruction of injured organ/structure indicated »
Severe pain; pain or analgesics severely interfering with ADL »
Symptomatic, interfering with ADL; operative intervention indicated (e.g., hardware/device replacement or removal, reconstruction) »
<11 - 8 mmol/L »
Symptomatic interfering with ADL; repair or revision indicated »
Complete resection or reconstruction of injured organ/structure indicated »
Severe limp with stride modified to maintain balance (widened base of support, marked reduction in step length); ambulation limited to walker; crutches… »
Complete resection or reconstruction of injured organ/structure indicated »
Symptomatic and interfering with ADL »
Operative debridement or other invasive intervention indicated (e.g., hyperbaric oxygen) »
Symptomatic interfering with ADL; repair or revision indicated »
Complete resection or reconstruction of injured organ/structure indicated »
Transfusion, interventional radiology, endoscopic, or operative intervention indicated; radiation therapy (i.e., hemostasis of bleeding site) »
Ankylosed/fused over multiple segments with no L-spine flexion (i.e., unable to reach to floor to pick up a very light object) … »
Symptomatic and associated with altered respiratory function interfering with ADL; or endoscopic (e.g., stent) or primary closure by operative intervention indicated … »
Transfusion, interventional radiology, endoscopic, or operative intervention indicated; radiation therapy (i.e., hemostasis of bleeding site) »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
Complete resection or reconstruction of injured organ/structure indicated »
Complete resection or reconstruction of injured organ/structure indicated »
Severe pain; pain or analgesics severely interfering with ADL »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
Very marked density and firmness with tethering affecting >=40% of the edematous area »
Symptomatic and interventional radiology or operative intervention indicated »
<500 - 200 mm(3) <0.5 - 0.2 x 10e9 /L »
Complete resection or reconstruction of injured organ/structure indicated »
Complete resection or reconstruction of injured organ/structure indicated »
Inability to aliment adequately via GI tract (i.e., TPN indicated) »
Transfusion, interventional radiology, endoscopic, or operative intervention indicated; radiation therapy (i.e., hemostasis of bleeding site) »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
Complete resection or reconstruction of injured organ/structure indicated »
Memory impairment interfering with ADL »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
Complete resection or reconstruction of injured organ/structure indicated »
3 point below age and educational norm in Folstein MMSE »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
CTCAE Grade 3 Middle Ear Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
Complete resection or reconstruction of injured organ/structure indicated »
Severe pain; pain or analgesics severely interfering with ADL »
Weakness interfering with ADL; bracing or assistance to walk (e.g., cane or walker) indicated »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
Complete resection or reconstruction of injured organ/structure indicated »
Severe pain; pain or analgesics severely interfering with ADL »
Functionally significant deformity, hypoplasia, or asymmetry, unable to be remediated by prosthesis or covered by clothing »
Weakness or sensory loss interfering with ADL »
Abnormal marrow cytogenetics (marrow blasts <=5%) »
CHF responsive to intervention »
Pain interfering with ADL »
Interfering with ADL »
Complete resection or reconstruction of injured organ/structure indicated »
Stenosis with significant nasal obstruction; interfering with ADL »
Complete resection or reconstruction of injured organ/structure indicated »
Complete resection or reconstruction of injured organ/structure indicated »
Inadequate oral caloric or fluid intake; IV fluids, tube feedings, or TPN indicated >=24 hrs »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
IV antibiotic, antifungal, or antiviral intervention indicated; interventional radiology or operative intervention indicated »
Complete resection or reconstruction of injured organ/structure indicated »
Severe pain; pain or analgesics severely interfering with ADL »
Operative debridement or other invasive intervention indicated (e.g., hyperbaric oxygen) »
Severe pain; pain or analgesics severely interfering with ADL »
Symptoms interfering with ADL; hospitalization indicated »
Symptoms interfering with ADL »
Symptoms interfering with ADL; osteopenia; fracture; infertility »
Symptoms interfering with ADL; amenorrhea; galactorrhea »
<1000 - 500/mm(3) <1.0 - 0.5 x 10e9 /L »
Symptomatic and incompletely controlled medically, or controlled with device (e.g., pacemaker) »
Symptomatic hernia without evidence of strangulation; fascial disruption/dehiscence without evisceration; primary wound closure or revision by operative intervention indicated; hospitalization or hyperbaric… »
Symptomatic, invasive procedure indicated »