Medicine

CTCAE Grade 4 Optic Disc Edema
Blindness (20/200 or worse) »
CTCAE Grade 4 Oral Cavity GI Fistula
CTCAE Grade 4 Oral Cavity Hemorrhage
Life-threatening consequences; major urgent intervention indicated »
CTCAE Grade 4 Oral Cavity Mucositis or Stomatitis by Clinical Examination Classification
Tissue necrosis; significant spontaneous bleeding; life-threatening consequences »
CTCAE Grade 4 Oral Cavity Mucositis or Stomatitis by Functional or Symptomatic Classification
Symptoms associated with life-threatening consequences »
CTCAE Grade 4 Oral Cavity NOS Intra-Operative Injury
Life threatening consequences; disabling »
CTCAE Grade 4 Oral Cavity or Gum Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils
Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis) »
CTCAE Grade 4 Oral Cavity or Gum Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils
Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis) »
CTCAE Grade 4 Oral Cavity or Gum Infection with Unknown Absolute Neutrophil Count
Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis) »
CTCAE Grade 4 Oral Cavity Pain
CTCAE Grade 4 Oral Cavity Pulmonary Fistula
Life-threatening consequences; operative intervention with thoracoplasty, chronic open drainage or multiple thoracotomies indicated »
CTCAE Grade 4 Oral Intra-Operative Injury
Life threatening consequences; disabling »
CTCAE Grade 4 Oral Necrosis
Life-threatening consequences; operative intervention requiring complete organ resection (e.g., total colectomy) »
CTCAE Grade 4 Oral Pain of the Gums
CTCAE Grade 4 Osteoporosis
CTCAE Grade 4 Other Allergy and Immunology
CTCAE Grade 4 Other Auditory and Ear
CTCAE Grade 4 Other Blood and Bone Marrow
CTCAE Grade 4 Other Cardiac Arrhythmia
CTCAE Grade 4 Other Coagulation
CTCAE Grade 4 Other Constitutional Symptoms
CTCAE Grade 4 Other Dermatology or Skin
CTCAE Grade 4 Other Endocrine
CTCAE Grade 4 Other Gastrointestinal
CTCAE Grade 4 Other Growth and Development
CTCAE Grade 4 Other Heart in General
CTCAE Grade 4 Other Hemorrhage and Bleeding
Catastrophic bleeding, requiring major non-elective intervention »
CTCAE Grade 4 Other Hepatobiliary and Pancreas
CTCAE Grade 4 Other Infection
CTCAE Grade 4 Other Intra-Operative Injury
Life threatening consequences; disabling »
CTCAE Grade 4 Other Lymphatics
CTCAE Grade 4 Other Metabolic and Laboratory
CTCAE Grade 4 Other Musculoskeletal and Soft Tissue
CTCAE Grade 4 Other Neurology
CTCAE Grade 4 Other NOS Artery Injury
Life-threatening; disabling; evidence of end organ damage (e.g., stroke, MI, organ or limb loss) »
CTCAE Grade 4 Other NOS Vein Injury
Life-threatening; disabling; evidence of end organ damage »
CTCAE Grade 4 Other Ocular and Visual
Blindness (20/200 or worse) »
CTCAE Grade 4 Other Pain
CTCAE Grade 4 Other Pulmonary and Upper Respiratory
CTCAE Grade 4 Other Renal or Genitourinary
CTCAE Grade 4 Other Secondary Malignancy Possibly Related to Cancer Treatment
Solid tumor, leukemia or lymphoma »
CTCAE Grade 4 Other Sexual Reproductive Function
CTCAE Grade 4 Other Syndromes
CTCAE Grade 4 Other Vascular
CTCAE Grade 4 Otitis External Ear Non Infectious
Necrosis of soft tissue or bone »
CTCAE Grade 4 Otitis Middle Ear Non Infectious
Necrosis of the canal soft tissue or bone »
CTCAE Grade 4 Outer Ear NOS Intra-Operative Injury
Life threatening consequences; disabling »
CTCAE Grade 4 Outer Ear Pinna Intra-Operative Injury
Life threatening consequences; disabling »
CTCAE Grade 4 Ovary Hemorrhage
Life-threatening consequences; major urgent intervention indicated »
CTCAE Grade 4 Ovary Intra-Operative Injury
Life threatening consequences; disabling »
CTCAE Grade 4 Ovary Perforation
Life-threatening consequences or organ failure; operative intervention requiring organ resection indicated »
CTCAE Grade 4 Ovulatory Pain
CTCAE Grade 4 Pain NOS
CTCAE Grade 4 Pancreas Exocrine Enzyme Deficiency
CTCAE Grade 4 Pancreas Fistula
CTCAE Grade 4 Pancreas Hemorrhage
Life-threatening consequences; major urgent intervention indicated »
CTCAE Grade 4 Pancreas Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils
Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis) »
CTCAE Grade 4 Pancreas Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils
Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis) »
CTCAE Grade 4 Pancreas Infection with Unknown Absolute Neutrophil Count
Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis) »
CTCAE Grade 4 Pancreas Intra-Operative Injury
Life threatening consequences; disabling »
CTCAE Grade 4 Pancreas Leak
CTCAE Grade 4 Pancreas Necrosis
Life-threatening consequences; operative intervention requiring complete organ resection (e.g., total colectomy) »
CTCAE Grade 4 Pancreas or Pancreatic Duct Stricture or Stenosis
Life-threatening consequences; operative intervention requiring complete organ resection (e.g., total colectomy) »
CTCAE Grade 4 Pancreatic Duct Intra-Operative Injury
Life threatening consequences; disabling »
CTCAE Grade 4 Pancreatic Endocrine Glucose Intolerance
Life-threatening consequences (e.g., ketoacidosis, hyperosmolar non-ketotic coma) »
CTCAE Grade 4 Pancreatitis
Life-threatening consequences (e.g., circulatory failure, hemorrhage, sepsis) »
CTCAE Grade 4 Paranasal Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils
Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis) »
CTCAE Grade 4 Paranasal Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils
Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis) »
CTCAE Grade 4 Paranasal Infection with Unknown Absolute Neutrophil Count
Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis) »
CTCAE Grade 4 Parathyroid Intra-Operative Injury
Life threatening consequences; disabling »
CTCAE Grade 4 Parotid Gland Intra-Operative Injury
Life threatening consequences; disabling »
CTCAE Grade 4 Pelvic Muscle Weakness Not Due to Neuropathy
CTCAE Grade 4 Pelvic Soft Tissue Necrosis
Life-threatening consequences; major invasive intervention indicated (e.g., tissue reconstruction, flap, or grafting) »
CTCAE Grade 4 Pelvis Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils
Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis) »
CTCAE Grade 4 Pelvis Infection NOS with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils
Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis) »
CTCAE Grade 4 Pelvis Infection NOS with Unknown Absolute Neutrophil Count
Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis) »
CTCAE Grade 4 Pelvis NOS Intra-Operative Injury
Life threatening consequences; disabling »
CTCAE Grade 4 Pelvis Pain
CTCAE Grade 4 Penis Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils
Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis) »
CTCAE Grade 4 Penis Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils
Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis) »
CTCAE Grade 4 Penis Infection with Unknown Absolute Neutrophil Count
Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis) »
CTCAE Grade 4 Penis Intra-Operative Injury
Life threatening consequences; disabling »
CTCAE Grade 4 Penis Pain
CTCAE Grade 4 Pericarditis
Life-threatening consequences; emergency intervention indicated »
CTCAE Grade 4 Pericardium Pain
CTCAE Grade 4 Perineum Pain
CTCAE Grade 4 Peripheral Arterial Ischemia
Life-threatening, disabling and/or associated with end organ damage (e.g., limb loss) »
CTCAE Grade 4 Peripheral Motor Nerve NOS Intra-Operative Injury
Life threatening consequences; disabling »
CTCAE Grade 4 Peripheral Nerve Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils
Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis) »
CTCAE Grade 4 Peripheral Nerve Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils
Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis) »
CTCAE Grade 4 Peripheral Nerve Infection with Unknown Absolute Neutrophil Count
Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis) »
CTCAE Grade 4 Peripheral Sensory Nerve NOS Intra-Operative Injury
Life threatening consequences; disabling »
CTCAE Grade 4 Peristomal Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils
Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis) »
CTCAE Grade 4 Peristomal Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils
Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis) »
CTCAE Grade 4 Peristomal Infection with Unknown Absolute Neutrophil Count
Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis) »
CTCAE Grade 4 Peritoneal Cavity Hemorrhage
Life-threatening consequences; major urgent intervention indicated »
CTCAE Grade 4 Peritoneal Cavity Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils
Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis) »
CTCAE Grade 4 Peritoneal Cavity Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils
Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis) »
CTCAE Grade 4 Peritoneal Cavity Infection with Unknown Absolute Neutrophil Count
Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis) »
CTCAE Grade 4 Peritoneal Cavity Intra-Operative Injury
Life threatening consequences; disabling »
CTCAE Grade 4 Peritoneal Cavity Necrosis
Life-threatening consequences; operative intervention requiring complete organ resection (e.g., total colectomy) »
CTCAE Grade 4 Peritoneum Pain
CTCAE Grade 4 Personality and Behavioral Change
Change harmful to others or self; hospitalization indicated »
CTCAE Grade 4 Phantom Pain Associated with Missing Limb
CTCAE Grade 4 Pharynx GI Fistula
CTCAE Grade 4 Pharynx Hemorrhage
Life-threatening consequences; major urgent intervention indicated »
CTCAE Grade 4 Pharynx Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils
Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis) »
CTCAE Grade 4 Pharynx Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils
Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis) »
CTCAE Grade 4 Pharynx Infection with Unknown Absolute Neutrophil Count
Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis) »
CTCAE Grade 4 Pharynx Intra-Operative Injury
Life threatening consequences; disabling »
CTCAE Grade 4 Pharynx Leak
CTCAE Grade 4 Pharynx Mucositis or Stomatitis by Clinical Examination Classification
Tissue necrosis; significant spontaneous bleeding; life-threatening consequences »
CTCAE Grade 4 Pharynx Mucositis or Stomatitis by Functional or Symptomatic Classification
Symptoms associated with life-threatening consequences »
CTCAE Grade 4 Pharynx Necrosis
Life-threatening consequences; operative intervention requiring complete organ resection (e.g., total colectomy) »
CTCAE Grade 4 Pharynx Obstruction and Stenosis
Life-threatening airway compromise; tracheotomy or intubation indicated »
CTCAE Grade 4 Pharynx Pulmonary Fistula
Life-threatening consequences; operative intervention with thoracoplasty, chronic open drainage or multiple thoracotomies indicated »
CTCAE Grade 4 Pharynx Stricture or Stenosis
Life-threatening consequences; operative intervention requiring complete organ resection (e.g., total colectomy) »
CTCAE Grade 4 Photophobia
CTCAE Grade 4 Photosensitivity
CTCAE Grade 4 Phrenic Nerve Dysfunction
Life-threatening respiratory compromise; mechanical ventilation indicated »
CTCAE Grade 4 Pituitary Intra-Operative Injury
Life threatening consequences; disabling »
CTCAE Grade 4 Platelets
<25,000/mm(3) <25.0 x 10e9 /L »
CTCAE Grade 4 Pleura Fistula
Life-threatening consequences; operative intervention with thoracoplasty, chronic open drainage or multiple thoracotomies indicated »
CTCAE Grade 4 Pleura Hemorrhage
Life-threatening consequences; major urgent intervention indicated »
CTCAE Grade 4 Pleura Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils
Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis) »
CTCAE Grade 4 Pleura Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils
Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis) »
CTCAE Grade 4 Pleura Infection with Unknown Absolute Neutrophil Count
Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis) »
CTCAE Grade 4 Pleura Intra-Operative Injury
Life threatening consequences; disabling »
CTCAE Grade 4 Pleura Pain
CTCAE Grade 4 Pneumonitis and Pulmonary Infiltrates
Life-threatening; ventilatory support indicated »
CTCAE Grade 4 Pneumothorax
Life-threatening, causing hemodynamic instability (e.g., tension pneumothorax); ventilatory support indicated »
CTCAE Grade 4 Portal Vein Intra-Operative Injury
Life threatening consequences; disabling »
CTCAE Grade 4 Proctitis
Life-threatening consequences (e.g., perforation) »
CTCAE Grade 4 Prolapse of Gastrointestinal Stoma
CTCAE Grade 4 Prolonged Chest Tube Drainage or Air Leak After Pulmonary Resection
Life-threatening; debilitating; organ resection indicated »
CTCAE Grade 4 Prolonged Intubation After Pulmonary Resection
CTCAE Grade 4 Prolonged QTc Interval
QTc >0.50 second; life-threatening signs or symptoms (e.g., arrhythmia, CHF, hypotension, shock syncope); Torsade de pointes »
CTCAE Grade 4 Prostate Hemorrhage
Life-threatening consequences; major urgent intervention indicated »
CTCAE Grade 4 Prostate Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils
Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis) »
CTCAE Grade 4 Prostate Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils
Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis) »
CTCAE Grade 4 Prostate Infection with Unknown Absolute Neutrophil Count
Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis) »
CTCAE Grade 4 Prostate Intra-Operative Injury
Life threatening consequences; disabling »
CTCAE Grade 4 Prostate Obstruction
Life-threatening consequences; organ failure or operative intervention requiring complete organ resection indicated »
CTCAE Grade 4 Prostate Pain
CTCAE Grade 4 Prostate Perforation
Life-threatening consequences or organ failure; operative intervention requiring organ resection indicated »
CTCAE Grade 4 Prostate Stricture or Stenosis
Life-threatening consequences; organ failure or operative intervention requiring organ resection indicated »
CTCAE Grade 4 Proteinuria
CTCAE Grade 4 Psychosis Including Hallucinations and Delusions
Harmful to others or self; life-threatening consequences »
CTCAE Grade 4 Pulmonary Artery Intra-Operative Injury
Life threatening consequences; disabling »
CTCAE Grade 4 Pulmonary Fibrosis Radiographic Changes
Estimated radiographic proportion of total lung volume that is fibrotic is >=75%; honeycombing »
CTCAE Grade 4 Pulmonary Hypertension
Symptomatic hypertension, poorly controlled »
CTCAE Grade 4 Pulmonary Vein Intra-Operative Injury
Life threatening consequences; disabling »
CTCAE Grade 4 PVCs
Life-threatening (e.g., arrhythmia associated with CHF, hypotension, syncope, shock) »
CTCAE Grade 4 Pyramidal Tract Dysfunction
CTCAE Grade 4 Radiation Excluding Chemoradiation
Skin necrosis or ulceration of full thickness dermis; spontaneous bleeding from involved site »
CTCAE Grade 4 Rash Desquamation
Generalized exfoliative, ulcerative, or bullous dermatitis »
CTCAE Grade 4 Rash Erythema Multiforme
CTCAE Grade 4 Rectal Varices Hemorrhage
Life-threatening consequences; major urgent intervention indicated »
CTCAE Grade 4 Rectum Fistula
CTCAE Grade 4 Rectum Hemorrhage
Life-threatening consequences; major urgent intervention indicated »
CTCAE Grade 4 Rectum Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils
Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis) »
CTCAE Grade 4 Rectum Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils
Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis) »
CTCAE Grade 4 Rectum Infection with Unknown Absolute Neutrophil Count
Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis) »
CTCAE Grade 4 Rectum Intra-Operative Injury
Life threatening consequences; disabling »
CTCAE Grade 4 Rectum Leak
CTCAE Grade 4 Rectum Mucositis or Stomatitis by Clinical Examination Classification
Tissue necrosis; significant spontaneous bleeding; life-threatening consequences »
CTCAE Grade 4 Rectum Mucositis or Stomatitis by Functional or Symptomatic Classification
Symptoms associated with life-threatening consequences »
CTCAE Grade 4 Rectum Necrosis
Life-threatening consequences; operative intervention requiring complete organ resection (e.g., total colectomy) »
CTCAE Grade 4 Rectum Obstruction
Life-threatening consequences; operative intervention requiring complete organ resection (e.g., total colectomy) »
CTCAE Grade 4 Rectum Pain
CTCAE Grade 4 Rectum Perforation
CTCAE Grade 4 Rectum Stricture or Stenosis
Life-threatening consequences; operative intervention requiring complete organ resection (e.g., total colectomy) »
CTCAE Grade 4 Rectum Ulcer
CTCAE Grade 4 Recurrent Laryngeal Nerve Intra-Operative Injury
Life threatening consequences; disabling »
CTCAE Grade 4 Renal Failure
Chronic dialysis or renal transplant indicated »
CTCAE Grade 4 Respiratory Tract Hemorrhage NOS
Life-threatening consequences; major urgent intervention indicated »
CTCAE Grade 4 Restrictive Cardiomyopathy
Refractory CHF, poorly controlled; intervention such as ventricular assist device, or heart transplant indicated »
CTCAE Grade 4 Retina Intra-Operative Injury
Life threatening consequences; disabling »
CTCAE Grade 4 Retinal Detachment
Blindness (20/200 or worse) »
CTCAE Grade 4 Retinoic Acid Syndrome
Life-threatening; ventilatory support indicated »
CTCAE Grade 4 Retinopathy
Blindness (20/200 or worse) »
CTCAE Grade 4 Retroperitoneum Hemorrhage
Life-threatening consequences; major urgent intervention indicated »
CTCAE Grade 4 Right Ventricular Dysfunction
Symptomatic cor pulmonale poorly controlled; intervention such as ventricular assist device, or heart transplant indicated »
CTCAE Grade 4 Right-Sided Muscle Weakness Not Due to Neuropathy
CTCAE Grade 4 Sacral Plexus Intra-Operative Injury
Life threatening consequences; disabling »
CTCAE Grade 4 Salivary Duct Intra-Operative Injury
Life threatening consequences; disabling »
CTCAE Grade 4 Salivary Gland Fistula
CTCAE Grade 4 Salivary Gland Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils
Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis) »
CTCAE Grade 4 Salivary Gland Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils
Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis) »
CTCAE Grade 4 Salivary Gland Infection with Unknown Absolute Neutrophil Count
Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis) »
CTCAE Grade 4 Salivary Gland Intra-Operative Injury
Life threatening consequences; disabling »
CTCAE Grade 4 Salivary Gland or Saliva Changes
CTCAE Grade 4 Scalp Pain
CTCAE Grade 4 Sciatic Nerve Intra-Operative Injury
Life threatening consequences; disabling »
CTCAE Grade 4 Scleral Necrosis and Melt
Blindness (20/200 or worse); painful eye with enucleation indicated »
CTCAE Grade 4 Scrotum Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils
Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis) »
CTCAE Grade 4 Scrotum Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils
Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis) »
CTCAE Grade 4 Scrotum Infection with Unknown Absolute Neutrophil Count
Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis) »
CTCAE Grade 4 Scrotum Intra-Operative Injury
Life threatening consequences; disabling »
CTCAE Grade 4 Scrotum Pain
CTCAE Grade 4 Seizure
Seizures of any kind which are prolonged, repetitive, or difficult to control (e.g., status epilepticus, intractable epilepsy) »
CTCAE Grade 4 Sensory Neuropathy
CTCAE Grade 4 Serum Glutamic Oxaloacetic Transaminase
CTCAE Grade 4 Serum Glutamic Pyruvic Transaminase
CTCAE Grade 4 Serum Hypercalcemia
13.5 mg/dL >3.4 mmol/L Ionized calcium >1.8 mmol/L »
CTCAE Grade 4 Serum Hypercholesteremia
500 mg/dL >12.92 mmol/L »
CTCAE Grade 4 Serum Hyperglycemia
500 mg/dL >27.8 mmol/L or acidosis »
CTCAE Grade 4 Serum Hyperkalemia
CTCAE Grade 4 Serum Hypermagnesemia
8.0 mg/dL >3.30 mmol/L »
CTCAE Grade 4 Serum Hypernatremia
CTCAE Grade 4 Serum Hypertriglyceridemia
CTCAE Grade 4 Serum Hyperuricemia
10 mg/dL >0.59 mmol/L »
CTCAE Grade 4 Serum Hypocalcemia
<6.0 mg/dL <1.5 mmol/L Ionized calcium <0.8 mmol/L »
CTCAE Grade 4 Serum Hypoglycemia
<30 mg/dL <1.7 mmol/L »
CTCAE Grade 4 Serum Hypokalemia
<2.5 mmol/L »
CTCAE Grade 4 Serum Hypomagnesemia
<0.7 mg/dL <0.3 mmol/L »
CTCAE Grade 4 Serum Hyponatremia
<120 mmol/L »
CTCAE Grade 4 Serum Hypophosphatemia
<1.0 mg/dL <0.3 mmol/L »
CTCAE Grade 4 Sick Sinus Syndrome
Life-threatening (e.g., arrhythmia associated with CHF, hypotension, syncope, shock) »
CTCAE Grade 4 Sinus Arrhythmia
Life-threatening (e.g., arrhythmia associated with CHF, hypotension, syncope, shock) »
CTCAE Grade 4 Sinus Bradycardia
Life-threatening (e.g., arrhythmia associated with CHF, hypotension, syncope, shock) »
CTCAE Grade 4 Sinus Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils
Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis) »
CTCAE Grade 4 Sinus Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils
Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis) »
CTCAE Grade 4 Sinus Infection with Unknown Absolute Neutrophil Count
Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis) »
CTCAE Grade 4 Sinus Intra-Operative Injury
Life threatening consequences; disabling »
CTCAE Grade 4 Sinus Pain
CTCAE Grade 4 Sinus Tachycardia
Life-threatening (e.g., arrhythmia associated with CHF, hypotension, syncope, shock) »
CTCAE Grade 4 Skin Breakdown or Decubitus Ulcer
Life-threatening consequences; major invasive intervention indicated (e.g., tissue reconstruction, flap, or grafting) »
CTCAE Grade 4 Skin Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils
Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis) »
CTCAE Grade 4 Skin Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils
Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis) »
CTCAE Grade 4 Skin Infection with Unknown Absolute Neutrophil Count
Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis) »
CTCAE Grade 4 Skin Intra-Operative Injury
Life threatening consequences; disabling »
CTCAE Grade 4 Skin Pain
CTCAE Grade 4 Slipped Capital Femoral Epiphysis
Disabling; severe slipped capital femoral epiphysis >60%; avascular necrosis »
CTCAE Grade 4 Small Bowel Fistula NOS
CTCAE Grade 4 Small Bowel Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils
Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis) »
CTCAE Grade 4 Small Bowel Infection NOS with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils
Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis) »
CTCAE Grade 4 Small Bowel Infection NOS with Unknown Absolute Neutrophil Count
Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis) »
CTCAE Grade 4 Small Bowel Leak
CTCAE Grade 4 Small Bowel Mucositis or Stomatitis by Clinical Examination Classification
Tissue necrosis; significant spontaneous bleeding; life-threatening consequences »
CTCAE Grade 4 Small Bowel Mucositis or Stomatitis by Functional or Symptomatic Classification
Symptoms associated with life-threatening consequences »
CTCAE Grade 4 Small Bowel Necrosis NOS
Life-threatening consequences; operative intervention requiring complete organ resection (e.g., total colectomy) »
CTCAE Grade 4 Small Bowel NOS Intra-Operative Injury
Life threatening consequences; disabling »
CTCAE Grade 4 Small Bowel Obstruction NOS
Life-threatening consequences; operative intervention requiring complete organ resection (e.g., total colectomy) »
CTCAE Grade 4 Small Bowel Perforation NOS
CTCAE Grade 4 Small Bowel Stricture or Stenosis NOS
Life-threatening consequences; operative intervention requiring complete organ resection (e.g., total colectomy) »
CTCAE Grade 4 Small Bowel Ulcer NOS
CTCAE Grade 4 Soft Tissue Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils
Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis) »
CTCAE Grade 4 Soft Tissue Infection NOS with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils
Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis) »
CTCAE Grade 4 Soft Tissue Infection NOS with Unknown Absolute Neutrophil Count
Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis) »
CTCAE Grade 4 Soft Tissue NOS Intra-Operative Injury
Life threatening consequences; disabling »
CTCAE Grade 4 Somnolence and Depressed Level of Consciousness
CTCAE Grade 4 Speech Impairment
Inability to communicate »
CTCAE Grade 4 Spermatic Cord Hemorrhage
Life-threatening consequences; major urgent intervention indicated »
CTCAE Grade 4 Spermatic Cord Leak
CTCAE Grade 4 Spermatic Cord Obstruction
Life-threatening consequences; organ failure or operative intervention requiring complete organ resection indicated »
CTCAE Grade 4 Spermatic Cord Perforation
Life-threatening consequences or organ failure; operative intervention requiring organ resection indicated »
CTCAE Grade 4 Spermatic Cord Stricture or Stenosis
Life-threatening consequences; organ failure or operative intervention requiring organ resection indicated »
CTCAE Grade 4 Spinal Cord Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils
Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis) »
CTCAE Grade 4 Spinal Cord Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils
Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis) »
CTCAE Grade 4 Spinal Cord Infection with Unknown Absolute Neutrophil Count
Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis) »
CTCAE Grade 4 Spinal Cord Intra-Operative Injury
Life threatening consequences; disabling »
CTCAE Grade 4 Spine Kyphosis or Lordosis
Disabling (e.g., cannot lift head) »
CTCAE Grade 4 Spine Scoliosis
Disabling (e.g., interfering with cardiopulmonary function) »
CTCAE Grade 4 Spleen Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils
Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis) »
CTCAE Grade 4 Spleen Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils
Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis) »
CTCAE Grade 4 Spleen Infection with Unknown Absolute Neutrophil Count
Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis) »
CTCAE Grade 4 Spleen Intra-Operative Injury
Life threatening consequences; disabling »
CTCAE Grade 4 Splenic Function
CTCAE Grade 4 Stokes-Adams Syndrome
Life-threatening (e.g., arrhythmia associated with CHF, hypotension, syncope, shock) »
CTCAE Grade 4 Stoma GI Obstruction
Life-threatening consequences; operative intervention requiring complete organ resection (e.g., total colectomy) »
CTCAE Grade 4 Stoma GI Stricture or Stenosis
Life-threatening consequences; operative intervention requiring complete organ resection (e.g., total colectomy) »
CTCAE Grade 4 Stoma Necrosis
Life-threatening consequences; operative intervention requiring complete organ resection (e.g., total colectomy) »
CTCAE Grade 4 Stoma Perforation
Life-threatening consequences or organ failure; operative intervention requiring organ resection indicated »
CTCAE Grade 4 Stoma Pulmonary Hemorrhage
Life-threatening consequences; major urgent intervention indicated »
CTCAE Grade 4 Stoma Ulcer
CTCAE Grade 4 Stomach Fistula
CTCAE Grade 4 Stomach Hemorrhage
Life-threatening consequences; major urgent intervention indicated »
CTCAE Grade 4 Stomach Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils
Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis) »
CTCAE Grade 4 Stomach Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils
Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis) »
CTCAE Grade 4 Stomach Infection with Unknown Absolute Neutrophil Count
Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis) »
CTCAE Grade 4 Stomach Intra-Operative Injury
Life threatening consequences; disabling »
CTCAE Grade 4 Stomach Leak
CTCAE Grade 4 Stomach Mucositis or Stomatitis by Clinical Examination Classification
Tissue necrosis; significant spontaneous bleeding; life-threatening consequences »
CTCAE Grade 4 Stomach Mucositis or Stomatitis by Functional or Symptomatic Classification
Symptoms associated with life-threatening consequences »
CTCAE Grade 4 Stomach Necrosis
Life-threatening consequences; operative intervention requiring complete organ resection (e.g., total colectomy) »
CTCAE Grade 4 Stomach Obstruction
Life-threatening consequences; operative intervention requiring complete organ resection (e.g., total colectomy) »
CTCAE Grade 4 Stomach Pain
CTCAE Grade 4 Stomach Perforation
CTCAE Grade 4 Stomach Stricture or Stenosis
Life-threatening consequences; operative intervention requiring complete organ resection (e.g., total colectomy) »
CTCAE Grade 4 Stomach Ulcer
CTCAE Grade 4 Superior Vena Cava Intra-Operative Injury
Life threatening consequences; disabling »
CTCAE Grade 4 Superior Vena Cava Vein Injury
Life-threatening; disabling; evidence of end organ damage »
CTCAE Grade 4 Supraventricular Arrhythmia NOS
Life-threatening (e.g., arrhythmia associated with CHF, hypotension, syncope, shock) »
CTCAE Grade 4 Supraventricular Extrasystoles
Life-threatening (e.g., arrhythmia associated with CHF, hypotension, syncope, shock) »
CTCAE Grade 4 Supraventricular Tachycardia
Life-threatening (e.g., arrhythmia associated with CHF, hypotension, syncope, shock) »
CTCAE Grade 4 Syncope
CTCAE Grade 4 Teeth Intra-Operative Injury
Life threatening consequences; disabling »
CTCAE Grade 4 Tendon Intra-Operative Injury
Life threatening consequences; disabling »
CTCAE Grade 4 Testes Hemorrhage
Life-threatening consequences; major urgent intervention indicated »
CTCAE Grade 4 Testes Obstruction
Life-threatening consequences; organ failure or operative intervention requiring complete organ resection indicated »
CTCAE Grade 4 Testes Perforation
Life-threatening consequences or organ failure; operative intervention requiring organ resection indicated »
CTCAE Grade 4 Testes Stricture or Stenosis
Life-threatening consequences; organ failure or operative intervention requiring organ resection indicated »
CTCAE Grade 4 Testicle Pain
CTCAE Grade 4 Testis Intra-Operative Injury
Life threatening consequences; disabling »
CTCAE Grade 4 Thoracic Duct Intra-Operative Injury
Life threatening consequences; disabling »
CTCAE Grade 4 Thoracodorsal Nerve Intra-Operative Injury
Life threatening consequences; disabling »
CTCAE Grade 4 Thorax Soft Tissue Necrosis
Life-threatening consequences; major invasive intervention indicated (e.g., tissue reconstruction, flap, or grafting) »
CTCAE Grade 4 Throat and Pharynx and Larynx Pain
CTCAE Grade 4 Thrombosis or Embolism Vascular Access Related
Embolic event including pulmonary embolism or life-threatening thrombus »
CTCAE Grade 4 Thrombosis or Thrombus or Embolism
Embolic event including pulmonary embolism or life-threatening thrombus »
CTCAE Grade 4 Thrombotic Microangiopathy
Laboratory findings and life-threatening or disabling consequences, (e.g., CNS hemorrhage/bleeding or thrombosis/embolism or renal failure) »
CTCAE Grade 4 Thyroid Function High
Life-threatening consequences (e.g., thyroid storm) »
CTCAE Grade 4 Thyroid Function Low
Life-threatening myxedema coma »
CTCAE Grade 4 Thyroid Intra-Operative Injury
Life threatening consequences; disabling »
CTCAE Grade 4 Tinnitus
CTCAE Grade 4 Tongue Intra-Operative Injury
Life threatening consequences; disabling »
CTCAE Grade 4 Torsade de Pointes
Life-threatening (e.g., arrhythmia associated with CHF, hypotension, syncope, shock) »
CTCAE Grade 4 Trachea Fistula
Life-threatening consequences; operative intervention with thoracoplasty, chronic open drainage or multiple thoracotomies indicated »
CTCAE Grade 4 Trachea Hemorrhage
Life-threatening consequences; major urgent intervention indicated »
CTCAE Grade 4 Trachea Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils
Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis) »
CTCAE Grade 4 Trachea Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils
Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis) »
CTCAE Grade 4 Trachea Infection with Unknown Absolute Neutrophil Count
Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis) »
CTCAE Grade 4 Trachea Intra-Operative Injury
Life threatening consequences; disabling »
CTCAE Grade 4 Trachea Mucositis or Stomatitis by Clinical Examination Classification
Tissue necrosis; significant spontaneous bleeding; life-threatening consequences »
CTCAE Grade 4 Trachea Mucositis or Stomatitis by Functional or Symptomatic Classification
Symptoms associated with life-threatening consequences »
CTCAE Grade 4 Trachea Obstruction and Stenosis
Life-threatening airway compromise; tracheotomy or intubation indicated »
CTCAE Grade 4 Tremor
CTCAE Grade 4 Trigeminy
Life-threatening (e.g., arrhythmia associated with CHF, hypotension, syncope, shock) »
CTCAE Grade 4 Trunk Muscle Weakness Not Due to Neuropathy
CTCAE Grade 4 Tumor Flare
CTCAE Grade 4 Tumor Pain
CTCAE Grade 4 Typhlitis
Life-threatening consequences (e.g., perforation, bleeding, ischemia, necrosis); operative intervention indicated »
CTCAE Grade 4 Ulceration
Life-threatening consequences; major invasive intervention indicated (e.g., complete resection, tissue reconstruction, flap, or grafting) »
CTCAE Grade 4 Ungual Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils
Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis) »
CTCAE Grade 4 Ungual Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils
Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis) »
CTCAE Grade 4 Ungual Infection with Unknown Absolute Neutrophil Count
Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis) »
CTCAE Grade 4 Upper Aerodigestive Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils
Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis) »
CTCAE Grade 4 Upper Aerodigestive Infection NOS with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils
Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis) »
CTCAE Grade 4 Upper Aerodigestive Infection NOS with Unknown Absolute Neutrophil Count
Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis) »
CTCAE Grade 4 Upper Aerodigestive NOS Intra-Operative Injury
Life threatening consequences; disabling »
CTCAE Grade 4 Upper Airway Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils
Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis) »
CTCAE Grade 4 Upper Airway Infection NOS with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils
Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis) »
CTCAE Grade 4 Upper Airway Infection NOS with Unknown Absolute Neutrophil Count
Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis) »
CTCAE Grade 4 Upper Airway NOS Intra-Operative Injury
Life threatening consequences; disabling »
CTCAE Grade 4 Upper Extremity Artery Injury
Life-threatening; disabling; evidence of end organ damage (e.g., stroke, MI, organ or limb loss) »
CTCAE Grade 4 Upper Extremity Artery Intra-Operative Injury
Life threatening consequences; disabling »
CTCAE Grade 4 Upper Extremity Function
Disabling; no function of affected limb »
CTCAE Grade 4 Upper Extremity Intra-Operative Injury
Life threatening consequences; disabling »
CTCAE Grade 4 Upper Extremity Muscle Weakness Not Due to Neuropathy
CTCAE Grade 4 Upper Extremity Soft Tissue Necrosis Adverse Event
Life-threatening consequences; major invasive intervention indicated (e.g., tissue reconstruction, flap, or grafting) »
CTCAE Grade 4 Upper Extremity Vein Injury
Life-threatening; disabling; evidence of end organ damage »
CTCAE Grade 4 Upper Extremity Vein Intra-Operative Injury
Life threatening consequences; disabling »
CTCAE Grade 4 Upper Gastrointestinal Hemorrhage NOS
Life-threatening consequences; major urgent intervention indicated »
CTCAE Grade 4 Ureter Fistula
Life-threatening consequences; operative intervention requiring partial or full organ resection; permanent urinary diversion »
CTCAE Grade 4 Ureter Hemorrhage
Life-threatening consequences; major urgent intervention indicated »
CTCAE Grade 4 Ureter Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils
Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis) »
CTCAE Grade 4 Ureter Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils
Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis) »
CTCAE Grade 4 Ureter Infection with Unknown Absolute Neutrophil Count
Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis) »
CTCAE Grade 4 Ureter Intra-Operative Injury
Life threatening consequences; disabling »
CTCAE Grade 4 Ureter Leak
CTCAE Grade 4 Ureter Obstruction
Life-threatening consequences; organ failure or operative intervention requiring complete organ resection indicated »
CTCAE Grade 4 Ureter Perforation
Life-threatening consequences or organ failure; operative intervention requiring organ resection indicated »
CTCAE Grade 4 Ureter Stricture or Stenosis
Life-threatening consequences; organ failure or operative intervention requiring organ resection indicated »
CTCAE Grade 4 Urethra Fistula
Life-threatening consequences; operative intervention requiring partial or full organ resection; permanent urinary diversion »
CTCAE Grade 4 Urethra Hemorrhage
Life-threatening consequences; major urgent intervention indicated »
CTCAE Grade 4 Urethra Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils
Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis) »
CTCAE Grade 4 Urethra Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils
Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis) »
CTCAE Grade 4 Urethra Infection with Unknown Absolute Neutrophil Count
Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis) »
CTCAE Grade 4 Urethra Intra-Operative Injury
Life threatening consequences; disabling »
CTCAE Grade 4 Urethra Leak
CTCAE Grade 4 Urethra Obstruction
Life-threatening consequences; organ failure or operative intervention requiring complete organ resection indicated »
CTCAE Grade 4 Urethra Pain
CTCAE Grade 4 Urethra Perforation
Life-threatening consequences or organ failure; operative intervention requiring organ resection indicated »
CTCAE Grade 4 Urethra Stricture or Stenosis
Life-threatening consequences; organ failure or operative intervention requiring organ resection indicated »
CTCAE Grade 4 Urinary Conduit Intra-Operative Injury
Life threatening consequences; disabling »
CTCAE Grade 4 Urinary Hemorrhage NOS
Life-threatening consequences; major urgent intervention indicated »
CTCAE Grade 4 Urinary Incontinence
Operative intervention indicated (e.g., cystectomy or permanent urinary diversion) »
CTCAE Grade 4 Urinary Retention
Life-threatening consequences; organ failure (e.g., bladder rupture); operative intervention requiring organ resection indicated »
CTCAE Grade 4 Urinary Tract Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils
Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis) »
CTCAE Grade 4 Urinary Tract Infection NOS with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils
Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis) »
CTCAE Grade 4 Urinary Tract Infection NOS with Unknown Absolute Neutrophil Count
Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis) »
CTCAE Grade 4 Urinary Tract NOS Intra-Operative Injury
Life threatening consequences; disabling »
CTCAE Grade 4 Uterus Fistula
Life-threatening consequences; operative intervention requiring partial or full organ resection; permanent urinary diversion »
CTCAE Grade 4 Uterus Hemorrhage
Life-threatening consequences; major urgent intervention indicated »
CTCAE Grade 4 Uterus Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils
Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis) »
CTCAE Grade 4 Uterus Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils
Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis) »
CTCAE Grade 4 Uterus Infection with Unknown Absolute Neutrophil Count
Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis) »
CTCAE Grade 4 Uterus Intra-Operative Injury
Life threatening consequences; disabling »
CTCAE Grade 4 Uterus Leak
CTCAE Grade 4 Uterus Obstruction
Life-threatening consequences; organ failure or operative intervention requiring complete organ resection indicated »
CTCAE Grade 4 Uterus Pain
CTCAE Grade 4 Uterus Perforation
Life-threatening consequences or organ failure; operative intervention requiring organ resection indicated »
CTCAE Grade 4 Uterus Stricture or Stenosis
Life-threatening consequences; organ failure or operative intervention requiring organ resection indicated »
CTCAE Grade 4 Uveitis
Blindness (20/200 or worse) »
CTCAE Grade 4 Vagina Fistula
Life-threatening consequences; operative intervention requiring partial or full organ resection; permanent urinary diversion »
CTCAE Grade 4 Vagina Hemorrhage
Life-threatening consequences; major urgent intervention indicated »
CTCAE Grade 4 Vagina Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils
Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis) »
CTCAE Grade 4 Vagina Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils
Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis) »
CTCAE Grade 4 Vagina Infection with Unknown Absolute Neutrophil Count
Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis) »
CTCAE Grade 4 Vagina Intra-Operative Injury
Life threatening consequences; disabling »
CTCAE Grade 4 Vagina Leak
CTCAE Grade 4 Vagina Obstruction
Life-threatening consequences; organ failure or operative intervention requiring complete organ resection indicated »
CTCAE Grade 4 Vagina Pain
CTCAE Grade 4 Vagina Perforation
Life-threatening consequences or organ failure; operative intervention requiring organ resection indicated »
CTCAE Grade 4 Vagina Stricture or Stenosis
Life-threatening consequences; organ failure or operative intervention requiring organ resection indicated »
CTCAE Grade 4 Vaginal Mucositis
Tissue necrosis; significant spontaneous bleeding; life-threatening consequences »
CTCAE Grade 4 Vaginitis Not Due to Infection
Ulceration and operative intervention indicated »
CTCAE Grade 4 Valvular Heart Disease
Life-threatening; disabling; intervention (e.g., valve replacement, valvuloplasty) indicated »
CTCAE Grade 4 Vas Deferens Hemorrhage
Life-threatening consequences; major urgent intervention indicated »
CTCAE Grade 4 Vas Deferens Leak
CTCAE Grade 4 Vas Deferens Obstruction
Life-threatening consequences; organ failure or operative intervention requiring complete organ resection indicated »
CTCAE Grade 4 Vas Deferens Perforation
Life-threatening consequences or organ failure; operative intervention requiring organ resection indicated »
CTCAE Grade 4 Vas Deferens Stricture or Stenosis
Life-threatening consequences; organ failure or operative intervention requiring organ resection indicated »
CTCAE Grade 4 Vasculitis
Ischemic changes; amputation indicated »
CTCAE Grade 4 Vasovagal Episode
CTCAE Grade 4 Vein Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils
Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis) »
CTCAE Grade 4 Vein Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils
Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis) »
CTCAE Grade 4 Vein Infection with Unknown Absolute Neutrophil Count
Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis) »
CTCAE Grade 4 Vein NOS Intra-Operative Injury
Life threatening consequences; disabling »
CTCAE Grade 4 Ventricular Arrhythmia NOS
Life-threatening (e.g., arrhythmia associated with CHF, hypotension, syncope, shock) »
CTCAE Grade 4 Ventricular Fibrillation
Life-threatening (e.g., arrhythmia associated with CHF, hypotension, syncope, shock) »
CTCAE Grade 4 Ventricular Flutter
Life-threatening (e.g., arrhythmia associated with CHF, hypotension, syncope, shock) »
CTCAE Grade 4 Ventricular Tachycardia
Life-threatening (e.g., arrhythmia associated with CHF, hypotension, syncope, shock) »
CTCAE Grade 4 Viral Hepatitis
Decompensated liver function (e.g., ascites, coagulopathy, encephalopathy, coma) »
CTCAE Grade 4 Viscera Vein Injury
Life-threatening; disabling; evidence of end organ damage »
CTCAE Grade 4 Visceral Artery Injury
Life-threatening; disabling; evidence of end organ damage (e.g., stroke, MI, organ or limb loss) »
CTCAE Grade 4 Vital Capacity
<25% of predicted value »
CTCAE Grade 4 Voice Changes and Dysarthria
Disabling; non-understandable voice or aphonic; requires voice aid (e.g., electrolarynx) for >50% of communication or requires >50% written communication »
CTCAE Grade 4 Vomiting
CTCAE Grade 4 Vulva Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils
Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis) »
CTCAE Grade 4 Vulva Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils
Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis) »
CTCAE Grade 4 Vulva Infection with Unknown Absolute Neutrophil Count
Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis) »
CTCAE Grade 4 Vulva Intra-Operative Injury
Life threatening consequences; disabling »
CTCAE Grade 4 Whole Body and Generalized Muscle Weakness Not Due to Neuropathy
CTCAE Grade 4 Wolff-Parkinson-White Syndrome
Life-threatening (e.g., arrhythmia associated with CHF, hypotension, syncope, shock) »
CTCAE Grade 4 Wound Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils
Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis) »
CTCAE Grade 4 Wound Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils
Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis) »
CTCAE Grade 4 Wound Infection with Unknown Absolute Neutrophil Count
Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis) »
CTCAE Grade 5 Abdomen Fistula NOS
CTCAE Grade 5 Abdomen Hemorrhage NOS
CTCAE Grade 5 Abdomen Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils
CTCAE Grade 5 Abdomen Infection NOS with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils
CTCAE Grade 5 Abdomen Infection NOS with Unknown Absolute Neutrophil Count
CTCAE Grade 5 Abdomen Soft Tissue Necrosis
CTCAE Grade 5 Acute Vascular Leak Syndrome
CTCAE Grade 5 Adrenal Insufficiency
CTCAE Grade 5 Adult Respiratory Distress Syndrome
CTCAE Grade 5 Agitation
CTCAE Grade 5 Alcohol Intolerance Antabuse-Like Syndrome
CTCAE Grade 5 Allergic Reaction and Hypersensitivity Including Drug Fever
CTCAE Grade 5 Anal Incontinence
CTCAE Grade 5 Anal or Perianal Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils
CTCAE Grade 5 Anal or Perianal Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils
CTCAE Grade 5 Anal or Perianal Infection with Unknown Absolute Neutrophil Count
CTCAE Grade 5 Anorexia
CTCAE Grade 5 Anus Fistula
CTCAE Grade 5 Anus Hemorrhage
CTCAE Grade 5 Anus Mucositis or Stomatitis by Clinical Examination Classification
CTCAE Grade 5 Anus Mucositis or Stomatitis by Functional or Symptomatic Classification
CTCAE Grade 5 Anus Necrosis
CTCAE Grade 5 Anus Stricture or Stenosis
CTCAE Grade 5 Anus Ulcer
CTCAE Grade 5 Anxiety
CTCAE Grade 5 Aorta Artery Injury
CTCAE Grade 5 Apnea
CTCAE Grade 5 Appendix Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils
CTCAE Grade 5 Appendix Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils
CTCAE Grade 5 Appendix Infection with Unknown Absolute Neutrophil Count
CTCAE Grade 5 Appendix Perforation
CTCAE Grade 5 Arachnoiditis and Meningismus and Radiculitis
CTCAE Grade 5 Artery Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils
CTCAE Grade 5 Artery Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils
CTCAE Grade 5 Artery Infection with Unknown Absolute Neutrophil Count
CTCAE Grade 5 Aspiration
CTCAE Grade 5 Asystole
CTCAE Grade 5 Ataxia
CTCAE Grade 5 Atelectasis
CTCAE Grade 5 Atrial Fibrillation
CTCAE Grade 5 Atrial Flutter
CTCAE Grade 5 Atrial Tachycardia or Paroxysmal Atrial Tachycardia
CTCAE Grade 5 Autoimmune Reaction
CTCAE Grade 5 AV Block First Degree
CTCAE Grade 5 AV Block Second Degree Mobitz Type I
CTCAE Grade 5 AV Block Second Degree Mobitz Type II
CTCAE Grade 5 AV Block Third Degree
CTCAE Grade 5 Avascular Osteonecrosis
CTCAE Grade 5 Bigeminy
CTCAE Grade 5 Biliary Tree Fistula
CTCAE Grade 5 Biliary Tree Hemorrhage
CTCAE Grade 5 Biliary Tree Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils
CTCAE Grade 5 Biliary Tree Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils
CTCAE Grade 5 Biliary Tree Infection with Unknown Absolute Neutrophil Count
CTCAE Grade 5 Biliary Tree Leak
CTCAE Grade 5 Biliary Tree Perforation
CTCAE Grade 5 Biliary Tree Stricture or Stenosis
CTCAE Grade 5 Bladder Fistula
CTCAE Grade 5 Bladder Hemorrhage
CTCAE Grade 5 Bladder Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils
CTCAE Grade 5 Bladder Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils
CTCAE Grade 5 Bladder Infection with Unknown Absolute Neutrophil Count
CTCAE Grade 5 Bladder Leak
CTCAE Grade 5 Bladder Obstruction
CTCAE Grade 5 Bladder Perforation
CTCAE Grade 5 Bladder Stricture or Stenosis
CTCAE Grade 5 Blood Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils
CTCAE Grade 5 Blood Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils
CTCAE Grade 5 Blood Infection with Unknown Absolute Neutrophil Count
CTCAE Grade 5 Bone Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils
CTCAE Grade 5 Bone Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils
CTCAE Grade 5 Bone Infection with Unknown Absolute Neutrophil Count
CTCAE Grade 5 Bone Marrow Cellularity
CTCAE Grade 5 Brachial Plexopathy
CTCAE Grade 5 Brain and Spinal Cord Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils
CTCAE Grade 5 Brain and Spinal Cord Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils
CTCAE Grade 5 Brain and Spinal Cord Infection with Unknown Absolute Neutrophil Count
CTCAE Grade 5 Brain Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils
CTCAE Grade 5 Brain Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils
CTCAE Grade 5 Brain Infection with Unknown Absolute Neutrophil Count
CTCAE Grade 5 Bronchopulmonary Hemorrhage NOS
CTCAE Grade 5 Bronchospasm and Wheezing
CTCAE Grade 5 Bronchus Fistula
CTCAE Grade 5 Bronchus Hemorrhage
CTCAE Grade 5 Bronchus Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils
CTCAE Grade 5 Bronchus Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils
CTCAE Grade 5 Bronchus Infection with Unknown Absolute Neutrophil Count
CTCAE Grade 5 Bronchus Obstruction and Stenosis
CTCAE Grade 5 Burn
CTCAE Grade 5 Carbon Monoxide Diffusion Capacity
CTCAE Grade 5 Cardiac Ischemia or Infarction
CTCAE Grade 5 Cardiac Troponin I
CTCAE Grade 5 Cardiac Troponin T
CTCAE Grade 5 Carotid Artery Injury
CTCAE Grade 5 Catheter-Related Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils
CTCAE Grade 5 Catheter-Related Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils
CTCAE Grade 5 Catheter-Related Infection with Unknown Absolute Neutrophil Count
CTCAE Grade 5 CD4 Count
CTCAE Grade 5 Cecum Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils
CTCAE Grade 5 Cecum Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils
CTCAE Grade 5 Cecum Infection with Unknown Absolute Neutrophil Count
CTCAE Grade 5 Cecum Obstruction
CTCAE Grade 5 Cecum or Appendix Hemorrhage
CTCAE Grade 5 Cecum Perforation
CTCAE Grade 5 Cecum Stricture or Stenosis
CTCAE Grade 5 Cecum Ulcer
CTCAE Grade 5 Central Nervous System Hemorrhage
CTCAE Grade 5 Cerebrospinal Fluid Leak
CTCAE Grade 5 Cervix Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils
CTCAE Grade 5 Cervix Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils
CTCAE Grade 5 Cervix Infection with Unknown Absolute Neutrophil Count
CTCAE Grade 5 Chemoradiation
CTCAE Grade 5 Cholecystitis
CTCAE Grade 5 Chyle or Lymph Leakage
CTCAE Grade 5 Chylothorax
CTCAE Grade 5 CNS Cerebrovascular Ischemia
CTCAE Grade 5 CNS Necrosis and Cystic Progression
CTCAE Grade 5 Cognitive Disturbance
CTCAE Grade 5 Colitis
CTCAE Grade 5 Colon Hemorrhage
CTCAE Grade 5 Colon Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils
CTCAE Grade 5 Colon Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils
CTCAE Grade 5 Colon Infection with Unknown Absolute Neutrophil Count
CTCAE Grade 5 Colon Obstruction
CTCAE Grade 5 Colon or Cecum or Appendix Fistula
CTCAE Grade 5 Colon or Cecum or Appendix Necrosis
CTCAE Grade 5 Colon Perforation
CTCAE Grade 5 Colon Stricture or Stenosis
CTCAE Grade 5 Colon Ulcer
CTCAE Grade 5 Conduction Abnormality NOS
CTCAE Grade 5 Confusion
CTCAE Grade 5 Conjunctiva Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils
CTCAE Grade 5 Conjunctiva Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils
CTCAE Grade 5 Conjunctiva Infection with Unknown Absolute Neutrophil Count
CTCAE Grade 5 Constipation
CTCAE Grade 5 Cornea Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils
CTCAE Grade 5 Cornea Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils
CTCAE Grade 5 Cornea Infection with Unknown Absolute Neutrophil Count
CTCAE Grade 5 Cranial Nerve I Neuropathy
CTCAE Grade 5 Cranial Nerve II Neuropathy
CTCAE Grade 5 Cranial Nerve III Neuropathy
CTCAE Grade 5 Cranial Nerve Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils
CTCAE Grade 5 Cranial Nerve Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils
CTCAE Grade 5 Cranial Nerve Infection with Unknown Absolute Neutrophil Count
CTCAE Grade 5 Cranial Nerve IV Neuropathy
CTCAE Grade 5 Cranial Nerve IX Neuropathy
CTCAE Grade 5 Cranial Nerve V Neuropathy
CTCAE Grade 5 Cranial Nerve VI Neuropathy
CTCAE Grade 5 Cranial Nerve VII Neuropathy
CTCAE Grade 5 Cranial Nerve VIII Neuropathy
CTCAE Grade 5 Cranial Nerve X Neuropathy
CTCAE Grade 5 Cranial Nerve XI Neuropathy
CTCAE Grade 5 Cranial Nerve XII Neuropathy
CTCAE Grade 5 Creatine Phosphokinase
CTCAE Grade 5 Creatinine
CTCAE Grade 5 Cystitis
CTCAE Grade 5 Cytokine Release Syndrome or Acute Infusion Reaction
CTCAE Grade 5 Death NOS
CTCAE Grade 5 Dehydration
CTCAE Grade 5 Dental-Tooth Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils
CTCAE Grade 5 Dental-Tooth Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils
CTCAE Grade 5 Dental-Tooth Infection with Unknown Absolute Neutrophil Count
CTCAE Grade 5 Depression
CTCAE Grade 5 Diarrhea
CTCAE Grade 5 Disease Progression NOS
CTCAE Grade 5 Disseminated Intravascular Coagulation
CTCAE Grade 5 Duodenum Fistula
CTCAE Grade 5 Duodenum Hemorrhage
CTCAE Grade 5 Duodenum Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils
CTCAE Grade 5 Duodenum Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils
CTCAE Grade 5 Duodenum Infection with Unknown Absolute Neutrophil Count
CTCAE Grade 5 Duodenum Necrosis
CTCAE Grade 5 Duodenum Obstruction
CTCAE Grade 5 Duodenum Perforation
CTCAE Grade 5 Duodenum Stricture or Stenosis
CTCAE Grade 5 Duodenum Ulcer
CTCAE Grade 5 Dysphagia
CTCAE Grade 5 Dyspnea
CTCAE Grade 5 Edema of the Head and Neck
CTCAE Grade 5 Edema of the Limb
CTCAE Grade 5 Edema of the Trunk and Genital Area
CTCAE Grade 5 Edema of the Viscera
CTCAE Grade 5 Encephalopathy
CTCAE Grade 5 Enteritis
CTCAE Grade 5 Esophageal Varices Hemorrhage
CTCAE Grade 5 Esophagitis
CTCAE Grade 5 Esophagus Fistula
CTCAE Grade 5 Esophagus Hemorrhage
CTCAE Grade 5 Esophagus Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils
CTCAE Grade 5 Esophagus Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils
CTCAE Grade 5 Esophagus Infection with Unknown Absolute Neutrophil Count
CTCAE Grade 5 Esophagus Leak
CTCAE Grade 5 Esophagus Mucositis or Stomatitis by Clinical Examination Classification
CTCAE Grade 5 Esophagus Mucositis or Stomatitis by Functional or Symptomatic Classification
CTCAE Grade 5 Esophagus Necrosis
CTCAE Grade 5 Esophagus Obstruction
CTCAE Grade 5 Esophagus Perforation
CTCAE Grade 5 Esophagus Stricture or Stenosis
CTCAE Grade 5 Esophagus Ulcer
CTCAE Grade 5 Euphoria
CTCAE Grade 5 Exostosis
CTCAE Grade 5 External Ear Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils
CTCAE Grade 5 External Ear Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils
CTCAE Grade 5 External Ear Infection with Unknown Absolute Neutrophil Count
CTCAE Grade 5 Extraocular Muscle Weakness Not Due to Neuropathy
CTCAE Grade 5 Extrapyramidal and Involuntary Movement and Restlessness
CTCAE Grade 5 Eye Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils
CTCAE Grade 5 Eye Infection NOS with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils
CTCAE Grade 5 Eye Infection NOS with Unknown Absolute Neutrophil Count
CTCAE Grade 5 Facial Muscle Weakness Not Due to Neuropathy
CTCAE Grade 5 Fallopian Tube Hemorrhage
CTCAE Grade 5 Fallopian Tube Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils
CTCAE Grade 5 Fallopian Tube Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils
CTCAE Grade 5 Fallopian Tube Infection with Unknown Absolute Neutrophil Count
CTCAE Grade 5 Fallopian Tube Leak
CTCAE Grade 5 Fallopian Tube Obstruction
CTCAE Grade 5 Fallopian Tube Perforation
CTCAE Grade 5 Fallopian Tube Stricture or Stenosis
CTCAE Grade 5 Febrile Neutropenia
CTCAE Grade 5 Female Genital Tract Fistula
CTCAE Grade 5 FEV1
CTCAE Grade 5 Fever Without Neutropenia
CTCAE Grade 5 Fibrinogen
CTCAE Grade 5 Fibrosis-Deep Connective Tissue
CTCAE Grade 5 Flu-Like Syndrome
CTCAE Grade 5 Foreign Body Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils
CTCAE Grade 5 Foreign Body Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils
CTCAE Grade 5 Foreign Body Infection with Unknown Absolute Neutrophil Count
CTCAE Grade 5 Fracture
CTCAE Grade 5 Gallbladder Fistula
CTCAE Grade 5 Gallbladder Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils
CTCAE Grade 5 Gallbladder Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils
CTCAE Grade 5 Gallbladder Infection with Unknown Absolute Neutrophil Count
CTCAE Grade 5 Gallbladder Necrosis
CTCAE Grade 5 Gallbladder Obstruction
CTCAE Grade 5 Gallbladder Perforation
CTCAE Grade 5 Gastritis
CTCAE Grade 5 Gastrointestinal Leak NOS
CTCAE Grade 5 Gastrointestinal Stoma Hemorrhage
CTCAE Grade 5 Gastrointestinal Stoma Leak
CTCAE Grade 5 Genitourinary Stoma Hemorrhage
CTCAE Grade 5 Genitourinary Stoma Leak
CTCAE Grade 5 Genitourinary Stoma Obstruction
CTCAE Grade 5 Genitourinary Stoma Prolapse
CTCAE Grade 5 Genitourinary Stoma Stricture or Stenosis
CTCAE Grade 5 Glomerular Filtration Rate
CTCAE Grade 5 Haptoglobin
CTCAE Grade 5 Head Soft Tissue Necrosis
CTCAE Grade 5 Heart Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils
CTCAE Grade 5 Heart Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils
CTCAE Grade 5 Heart Infection with Unknown Absolute Neutrophil Count
CTCAE Grade 5 Hematoma
CTCAE Grade 5 Hemoglobin
CTCAE Grade 5 Hemoglobinuria
CTCAE Grade 5 Hemolysis
CTCAE Grade 5 Hemorrhage and Bleeding Adverse Event Associated with Surgery
CTCAE Grade 5 Hemorrhoids
CTCAE Grade 5 Hepatic Necrosis
CTCAE Grade 5 Hydrocephalus
CTCAE Grade 5 Hypertension
CTCAE Grade 5 Hypotension
CTCAE Grade 5 Hypothermia
CTCAE Grade 5 Hypoxia
CTCAE Grade 5 Idioventricular Rhythm
CTCAE Grade 5 Ileum Fistula
CTCAE Grade 5 Ileum Hemorrhage
CTCAE Grade 5 Ileum Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils
CTCAE Grade 5 Ileum Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils
CTCAE Grade 5 Ileum Infection with Unknown Absolute Neutrophil Count
CTCAE Grade 5 Ileum Necrosis
CTCAE Grade 5 Ileum Obstruction
CTCAE Grade 5 Ileum Perforation
CTCAE Grade 5 Ileum Stricture or Stenosis
CTCAE Grade 5 Ileum Ulcer
CTCAE Grade 5 Ileus
CTCAE Grade 5 Infectious Colitis
CTCAE Grade 5 Inferior Vena Cava Vein Injury
CTCAE Grade 5 Iron Overload
CTCAE Grade 5 Jejunum Fistula
CTCAE Grade 5 Jejunum Hemorrhage
CTCAE Grade 5 Jejunum Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils
CTCAE Grade 5 Jejunum Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils
CTCAE Grade 5 Jejunum Infection with Unknown Absolute Neutrophil Count
CTCAE Grade 5 Jejunum Necrosis
CTCAE Grade 5 Jejunum Obstruction
CTCAE Grade 5 Jejunum Perforation
CTCAE Grade 5 Jejunum Stricture or Stenosis
CTCAE Grade 5 Jejunum Ulcer
CTCAE Grade 5 Joint Effusion
CTCAE Grade 5 Joint Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils
CTCAE Grade 5 Joint Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils
CTCAE Grade 5 Joint Infection with Unknown Absolute Neutrophil Count
CTCAE Grade 5 Jugular Vein Injury
CTCAE Grade 5 Kidney Fistula
CTCAE Grade 5 Kidney Hemorrhage
CTCAE Grade 5 Kidney Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils
CTCAE Grade 5 Kidney Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils
CTCAE Grade 5 Kidney Infection with Unknown Absolute Neutrophil Count
CTCAE Grade 5 Kidney Leak
CTCAE Grade 5 Kidney Perforation
CTCAE Grade 5 Large Bowel Leak
CTCAE Grade 5 Large Bowel Mucositis or Stomatitis by Clinical Examination Classification
CTCAE Grade 5 Large Bowel Mucositis or Stomatitis by Functional or Symptomatic Classification
CTCAE Grade 5 Laryngeal Nerve Dysfunction
CTCAE Grade 5 Larynx Edema
CTCAE Grade 5 Larynx Fistula
CTCAE Grade 5 Larynx Hemorrhage
CTCAE Grade 5 Larynx Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils
CTCAE Grade 5 Larynx Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils
CTCAE Grade 5 Larynx Infection with Unknown Absolute Neutrophil Count
CTCAE Grade 5 Larynx Mucositis or Stomatitis by Clinical Examination Classification
CTCAE Grade 5 Larynx Mucositis or Stomatitis by Functional or Symptomatic Classification
CTCAE Grade 5 Larynx Obstruction and Stenosis
CTCAE Grade 5 Left Ventricular Diastolic Dysfunction
CTCAE Grade 5 Left Ventricular Systolic Dysfunction
CTCAE Grade 5 Left-Sided Muscle Weakness Not Due to Neuropathy
CTCAE Grade 5 Lens Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils
CTCAE Grade 5 Lens Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils
CTCAE Grade 5 Lens Infection with Unknown Absolute Neutrophil Count
CTCAE Grade 5 Leukocytes
CTCAE Grade 5 Lip or Perioral Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils
CTCAE Grade 5 Lip or Perioral Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils
CTCAE Grade 5 Lip or Perioral Infection with Unknown Absolute Neutrophil Count
CTCAE Grade 5 Liver Dysfunction or Failure by Clinical Classification
CTCAE Grade 5 Liver Hemorrhage
CTCAE Grade 5 Liver Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils
CTCAE Grade 5 Liver Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils
CTCAE Grade 5 Liver Infection with Unknown Absolute Neutrophil Count
CTCAE Grade 5 Local Complication of Device and Prosthesis
CTCAE Grade 5 Low Serum Bicarbonate
CTCAE Grade 5 Lower Extremity Artery Injury
CTCAE Grade 5 Lower Extremity Muscle Weakness Not Due to Neuropathy
CTCAE Grade 5 Lower Extremity Soft Tissue Necrosis
CTCAE Grade 5 Lower Extremity Vein Injury
CTCAE Grade 5 Lower Gastrointestinal Hemorrhage NOS
CTCAE Grade 5 Lung Fistula
CTCAE Grade 5 Lung Hemorrhage
CTCAE Grade 5 Lung Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils
CTCAE Grade 5 Lung Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils
CTCAE Grade 5 Lung Infection with Unknown Absolute Neutrophil Count
CTCAE Grade 5 Lymphatic Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils
CTCAE Grade 5 Lymphatic Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils
CTCAE Grade 5 Lymphatic Infection with Unknown Absolute Neutrophil Count
CTCAE Grade 5 Lymphopenia
CTCAE Grade 5 Malabsorption
CTCAE Grade 5 Mediastinum Hemorrhage
CTCAE Grade 5 Mediastinum Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils
CTCAE Grade 5 Mediastinum Infection NOS with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils
CTCAE Grade 5 Mediastinum Infection NOS with Unknown Absolute Neutrophil Count
CTCAE Grade 5 Meninges Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils
CTCAE Grade 5 Meninges Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils
CTCAE Grade 5 Meninges Infection with Unknown Absolute Neutrophil Count
CTCAE Grade 5 Metabolic or Respiratory Acidosis
CTCAE Grade 5 Metabolic or Respiratory Alkalosis
CTCAE Grade 5 Middle Ear Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils
CTCAE Grade 5 Middle Ear Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils
CTCAE Grade 5 Middle Ear Infection with Unknown Absolute Neutrophil Count
CTCAE Grade 5 Motor Neuropathy
CTCAE Grade 5 Mucosa Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils
CTCAE Grade 5 Mucosa Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils
CTCAE Grade 5 Mucosa Infection with Unknown Absolute Neutrophil Count
CTCAE Grade 5 Multi-Organ Failure
CTCAE Grade 5 Muscle Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils
CTCAE Grade 5 Muscle Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils
CTCAE Grade 5 Muscle Infection with Unknown Absolute Neutrophil Count
CTCAE Grade 5 Myelitis
CTCAE Grade 5 Myelodysplasia
CTCAE Grade 5 Myocarditis
CTCAE Grade 5 Myositis
CTCAE Grade 5 Nasal Cavity and Paranasal Sinus Reactions
CTCAE Grade 5 Nausea
CTCAE Grade 5 Neck Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils
CTCAE Grade 5 Neck Infection NOS with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils
CTCAE Grade 5 Neck Infection NOS with Unknown Absolute Neutrophil Count
CTCAE Grade 5 Neck Soft Tissue Necrosis
CTCAE Grade 5 Neuroendocrine ACTH Deficiency
CTCAE Grade 5 Neuroendocrine ADH Secretion Abnormality
CTCAE Grade 5 Neuroendocrine Prolactin Hormone Secretion Abnormality
CTCAE Grade 5 Neutrophils and Granulocytes
CTCAE Grade 5 Nodal or Junctional Rhythm
CTCAE Grade 5 Non-Infectious Wound Complication
CTCAE Grade 5 Non-Malignant Ascites
CTCAE Grade 5 Non-Malignant Pericardial Effusion
CTCAE Grade 5 Non-Malignant Pleural Effusion
CTCAE Grade 5 Non-Myocardial Visceral Arterial Ischemia
CTCAE Grade 5 Non-Septic Arthritis
CTCAE Grade 5 Nose Hemorrhage
CTCAE Grade 5 Nose Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils
CTCAE Grade 5 Nose Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils
CTCAE Grade 5 Nose Infection with Unknown Absolute Neutrophil Count
CTCAE Grade 5 Ocular Muscle Weakness Not Due to Neuropathy
CTCAE Grade 5 Opportunistic Infection
CTCAE Grade 5 Oral Cavity GI Fistula
CTCAE Grade 5 Oral Cavity Hemorrhage
CTCAE Grade 5 Oral Cavity Mucositis or Stomatitis by Clinical Examination Classification
CTCAE Grade 5 Oral Cavity Mucositis or Stomatitis by Functional or Symptomatic Classification
CTCAE Grade 5 Oral Cavity or Gum Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils
CTCAE Grade 5 Oral Cavity or Gum Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils
CTCAE Grade 5 Oral Cavity or Gum Infection with Unknown Absolute Neutrophil Count
CTCAE Grade 5 Oral Cavity Pulmonary Fistula
CTCAE Grade 5 Oral Necrosis
CTCAE Grade 5 Osteoporosis
CTCAE Grade 5 Other Allergy and Immunology
CTCAE Grade 5 Other Auditory and Ear
CTCAE Grade 5 Other Blood and Bone Marrow
CTCAE Grade 5 Other Cardiac Arrhythmia
CTCAE Grade 5 Other Coagulation
CTCAE Grade 5 Other Constitutional Symptoms
CTCAE Grade 5 Other Dermatology or Skin
CTCAE Grade 5 Other Endocrine
CTCAE Grade 5 Other Gastrointestinal
CTCAE Grade 5 Other Growth and Development
CTCAE Grade 5 Other Heart in General
CTCAE Grade 5 Other Hemorrhage and Bleeding
CTCAE Grade 5 Other Hepatobiliary and Pancreas
CTCAE Grade 5 Other Infection
CTCAE Grade 5 Other Lymphatics
CTCAE Grade 5 Other Metabolic and Laboratory
CTCAE Grade 5 Other Musculoskeletal and Soft Tissue
CTCAE Grade 5 Other Neurology
CTCAE Grade 5 Other NOS Artery Injury
CTCAE Grade 5 Other NOS Vein Injury
CTCAE Grade 5 Other Ocular and Visual
CTCAE Grade 5 Other Pulmonary and Upper Respiratory
CTCAE Grade 5 Other Renal or Genitourinary
CTCAE Grade 5 Other Secondary Malignancy Possibly Related to Cancer Treatment
CTCAE Grade 5 Other Sexual Reproductive Function
CTCAE Grade 5 Other Syndromes
CTCAE Grade 5 Other Vascular
CTCAE Grade 5 Otitis External Ear Non Infectious
CTCAE Grade 5 Otitis Middle Ear Non Infectious
CTCAE Grade 5 Ovary Hemorrhage
CTCAE Grade 5 Ovary Perforation
CTCAE Grade 5 Pancreas Exocrine Enzyme Deficiency
CTCAE Grade 5 Pancreas Fistula
CTCAE Grade 5 Pancreas Hemorrhage
CTCAE Grade 5 Pancreas Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils
CTCAE Grade 5 Pancreas Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils
CTCAE Grade 5 Pancreas Infection with Unknown Absolute Neutrophil Count
CTCAE Grade 5 Pancreas Leak
CTCAE Grade 5 Pancreas Necrosis
CTCAE Grade 5 Pancreas or Pancreatic Duct Stricture or Stenosis
CTCAE Grade 5 Pancreatic Endocrine Glucose Intolerance
CTCAE Grade 5 Pancreatitis
CTCAE Grade 5 Paranasal Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils
CTCAE Grade 5 Paranasal Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils
CTCAE Grade 5 Paranasal Infection with Unknown Absolute Neutrophil Count
CTCAE Grade 5 Pelvic Muscle Weakness Not Due to Neuropathy
CTCAE Grade 5 Pelvic Soft Tissue Necrosis
CTCAE Grade 5 Pelvis Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils
CTCAE Grade 5 Pelvis Infection NOS with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils
CTCAE Grade 5 Pelvis Infection NOS with Unknown Absolute Neutrophil Count
CTCAE Grade 5 Penis Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils
CTCAE Grade 5 Penis Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils
CTCAE Grade 5 Penis Infection with Unknown Absolute Neutrophil Count
CTCAE Grade 5 Pericarditis
CTCAE Grade 5 Peripheral Arterial Ischemia
CTCAE Grade 5 Peripheral Nerve Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils
CTCAE Grade 5 Peripheral Nerve Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils
CTCAE Grade 5 Peripheral Nerve Infection with Unknown Absolute Neutrophil Count
CTCAE Grade 5 Peristomal Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils
CTCAE Grade 5 Peristomal Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils
CTCAE Grade 5 Peristomal Infection with Unknown Absolute Neutrophil Count
CTCAE Grade 5 Peritoneal Cavity Hemorrhage
CTCAE Grade 5 Peritoneal Cavity Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils
CTCAE Grade 5 Peritoneal Cavity Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils
CTCAE Grade 5 Peritoneal Cavity Infection with Unknown Absolute Neutrophil Count
CTCAE Grade 5 Peritoneal Cavity Necrosis
CTCAE Grade 5 Personality and Behavioral Change
CTCAE Grade 5 Pharynx GI Fistula
CTCAE Grade 5 Pharynx Hemorrhage
CTCAE Grade 5 Pharynx Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils
CTCAE Grade 5 Pharynx Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils
CTCAE Grade 5 Pharynx Infection with Unknown Absolute Neutrophil Count
CTCAE Grade 5 Pharynx Leak
CTCAE Grade 5 Pharynx Mucositis or Stomatitis by Clinical Examination Classification
CTCAE Grade 5 Pharynx Mucositis or Stomatitis by Functional or Symptomatic Classification
CTCAE Grade 5 Pharynx Necrosis
CTCAE Grade 5 Pharynx Obstruction and Stenosis
CTCAE Grade 5 Pharynx Pulmonary Fistula
CTCAE Grade 5 Pharynx Stricture or Stenosis
CTCAE Grade 5 Photosensitivity
CTCAE Grade 5 Phrenic Nerve Dysfunction
CTCAE Grade 5 Platelets
CTCAE Grade 5 Pleura Fistula
CTCAE Grade 5 Pleura Hemorrhage
CTCAE Grade 5 Pleura Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils
CTCAE Grade 5 Pleura Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils
CTCAE Grade 5 Pleura Infection with Unknown Absolute Neutrophil Count
CTCAE Grade 5 Pneumonitis and Pulmonary Infiltrates
CTCAE Grade 5 Pneumothorax
CTCAE Grade 5 Proctitis
CTCAE Grade 5 Prolapse of Gastrointestinal Stoma
CTCAE Grade 5 Prolonged Chest Tube Drainage or Air Leak After Pulmonary Resection
CTCAE Grade 5 Prolonged Intubation After Pulmonary Resection
CTCAE Grade 5 Prolonged QTc Interval
CTCAE Grade 5 Prostate Hemorrhage
CTCAE Grade 5 Prostate Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils
CTCAE Grade 5 Prostate Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils
CTCAE Grade 5 Prostate Infection with Unknown Absolute Neutrophil Count
CTCAE Grade 5 Prostate Obstruction
CTCAE Grade 5 Prostate Perforation
CTCAE Grade 5 Prostate Stricture or Stenosis
CTCAE Grade 5 Proteinuria
CTCAE Grade 5 Psychosis Including Hallucinations and Delusions
CTCAE Grade 5 Pulmonary Fibrosis Radiographic Changes
CTCAE Grade 5 Pulmonary Hypertension
CTCAE Grade 5 PVCs
CTCAE Grade 5 Pyramidal Tract Dysfunction
CTCAE Grade 5 Radiation Excluding Chemoradiation
CTCAE Grade 5 Rash Acne or Acneiform Adverse Event
CTCAE Grade 5 Rash Desquamation
CTCAE Grade 5 Rash Erythema Multiforme
CTCAE Grade 5 Rectal Varices Hemorrhage
CTCAE Grade 5 Rectum Fistula
CTCAE Grade 5 Rectum Hemorrhage
CTCAE Grade 5 Rectum Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils
CTCAE Grade 5 Rectum Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils
CTCAE Grade 5 Rectum Infection with Unknown Absolute Neutrophil Count
CTCAE Grade 5 Rectum Leak
CTCAE Grade 5 Rectum Mucositis or Stomatitis by Clinical Examination Classification
CTCAE Grade 5 Rectum Mucositis or Stomatitis by Functional or Symptomatic Classification
CTCAE Grade 5 Rectum Necrosis
CTCAE Grade 5 Rectum Obstruction
CTCAE Grade 5 Rectum Perforation
CTCAE Grade 5 Rectum Stricture or Stenosis
CTCAE Grade 5 Rectum Ulcer
CTCAE Grade 5 Renal Failure
CTCAE Grade 5 Respiratory Tract Hemorrhage NOS
CTCAE Grade 5 Restrictive Cardiomyopathy
CTCAE Grade 5 Retinoic Acid Syndrome
CTCAE Grade 5 Retroperitoneum Hemorrhage
CTCAE Grade 5 Right Ventricular Dysfunction
CTCAE Grade 5 Right-Sided Muscle Weakness Not Due to Neuropathy
CTCAE Grade 5 Salivary Gland Fistula
CTCAE Grade 5 Salivary Gland Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils
CTCAE Grade 5 Salivary Gland Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils
CTCAE Grade 5 Salivary Gland Infection with Unknown Absolute Neutrophil Count
CTCAE Grade 5 Scrotum Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils
CTCAE Grade 5 Scrotum Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils
CTCAE Grade 5 Scrotum Infection with Unknown Absolute Neutrophil Count
CTCAE Grade 5 Seizure
CTCAE Grade 5 Sensory Neuropathy
CTCAE Grade 5 Serum Hypercalcemia
CTCAE Grade 5 Serum Hypercholesteremia
CTCAE Grade 5 Serum Hyperglycemia
CTCAE Grade 5 Serum Hyperkalemia
CTCAE Grade 5 Serum Hypermagnesemia
CTCAE Grade 5 Serum Hypernatremia
CTCAE Grade 5 Serum Hypertriglyceridemia
CTCAE Grade 5 Serum Hyperuricemia
CTCAE Grade 5 Serum Hypoalbuminemia
CTCAE Grade 5 Serum Hypocalcemia
CTCAE Grade 5 Serum Hypoglycemia
CTCAE Grade 5 Serum Hypokalemia
CTCAE Grade 5 Serum Hypomagnesemia
CTCAE Grade 5 Serum Hyponatremia
CTCAE Grade 5 Serum Hypophosphatemia
CTCAE Grade 5 Serum Sickness
CTCAE Grade 5 Sick Sinus Syndrome
CTCAE Grade 5 Sinus Arrhythmia


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