Mefloquine

A quinolinemethanol derivative with antimalarial, anti-inflammatory, and potential chemosensitization and radiosensitization activities. Although the exact mechanism remains to be elucidated, mefloquine, a weak base, preferentially accumulates in lysosomes and disrupts lysosomal function and integrity, thereby leading to host cell death. Similar to chloroquine, the chemosensitizing and radiosensitizing activities of this agent may be related to its inhibition of autophagocytosis, a cellular mechanism involving lysosomal degradation that minimizes the production of reactive oxygen species (ROS) related to tumor reoxygenation and tumor exposure to chemotherapeutic agents and radiation. Compared to chloroquine, mefloquine has better blood-brain-barrier (BBB) penetration. (NCI Thesaurus)

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Mefenamic Acid

An anthranilic acid and non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, antipyretic and analgesic activities. Mefenamic acid inhibits the activity of the enzymes…

MEF2D wt Allele

Human MEF2D wild-type allele is located within 1q12-q23 and is approximately 37 kb in length. This allele, which encodes myocyte-specific enhancer factor…

MEF2D Gene

This gene plays a role in muscle and neuronal development.

MEF2C wt Allele

Human MEF2C wild-type allele is located in the vicinity of 5q14 and is approximately 186 kb in length. This allele, which encodes…

MEF2C Gene

This gene plays a role in muscular and vascular development.

MEF2B wt Allele

Human MEF2B wild-type allele is located in the vicinity of 19p13.11 and is approximately 47 kb in length. This allele, which encodes…